WBP2 Antibody (C-6): sc-514246
- WBP2 Antibody (C-6) is a mouse monoclonal IgG2b (lambda light chain) provided at 200 µg/ml
- specific for an epitope mapping between amino acids 129-150 within an internal region of WBP2 of human origin
- recommended for detection of WBP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for WBP2 Antibody (C-6) for WB applications. This reagent is now offered in a bundle with WBP2 Antibody (C-6) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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WBP2 Antibody (C-6) is a mouse monoclonal IgG2b antibody that detects WW domain-binding protein 2 (WBP2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WBP2 is a 261 amino acid protein predominantly expressed in various tissues, playing a crucial role in mediating protein-protein interactions via its WW domain, which consists of 38 to 40 semi-conserved amino acids. This domain is essential for binding to polyproline ligands, facilitating interactions with key regulatory proteins such as Yes-associated protein (YAP) and E3 ubiquitin ligases AIP5 and AIP2. WBP2 interaction with these proteins influences cellular signaling pathways vital for processes like cell proliferation and apoptosis. The gene encoding WBP2 is located on human chromosome 17, a region associated with several critical genes involved in tumor suppression and the pathogenesis of various cancers, including Li-Fraumeni syndrome and early onset breast cancer. Anti-WBP2 antibody (C-6) enables researchers to gain insights into the functional dynamics of WBP2 and its role in cancer biology, making this tool invaluable for studies in molecular and cellular biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WBP2 Antibody (C-6) | sc-514246 | 200 µg/ml | $322.00 | |||
WBP2 Antibody (C-6): m-IgGλ BP-HRP Bundle | sc-524662 | 200 µg Ab, 40 µg BP | $361.00 | |||
WBP2 (C-6) Neutralizing Peptide | sc-514246 P | 100 µg/0.5 ml | $69.00 |