WBP2 Antibody (D-12): sc-514247
- WBP2 Antibody (D-12) is a mouse monoclonal IgG1 λ WBP2 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 129-150 within an internal region of WBP2 of human origin
- WBP2 Antibody (D-12) is recommended for detection of WBP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-WBP2 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for WBP2 Antibody (D-12) for WB applications. This reagent is now offered in a bundle with WBP2 Antibody (D-12) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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WBP2 Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects WBP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WBP2 (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WW domain-binding protein 2 (WBP2) is a 261 amino acid protein predominantly expressed in various tissues, playing a crucial role in cellular signaling and regulation. WBP2′s structure features a WW domain, which consists of 38 to 40 semi-conserved amino acids that facilitate protein-protein interactions by binding to polyproline ligands. This interaction is vital for the regulation of key signaling pathways, particularly those involving Yes-associated protein (YAP) and E3 ubiquitin ligases, which are implicated in processes such as cell proliferation and apoptosis. The gene encoding WBP2 is located on human chromosome 17, a region associated with several critical genes involved in tumor suppression and the pathogenesis of various cancers, including breast and ovarian cancer. Using anti-WBP2 antibody (D-12) in research can provide insights into the molecular mechanisms underlying these diseases and explore potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WBP2 Antibody (D-12) References:
- Identification of the WW domain-interaction sites in the unstructured N-terminal domain of EBV LMP 2A. | Seo, MD., et al. 2007. FEBS Lett. 581: 65-70. PMID: 17174309
- Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. | Raikwar, NS. and Thomas, CP. 2008. Am J Physiol Renal Physiol. 294: F1157-65. PMID: 18322022
- Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration. | Qin, H., et al. 2008. Biochemistry. 47: 13647-58. PMID: 19035836
- The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. | Feng, SM., et al. 2009. Mol Cell Biol. 29: 892-906. PMID: 19047365
- YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease. | Wang, K., et al. 2009. Biochem Cell Biol. 87: 77-91. PMID: 19234525
- The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. | Chen, HI. and Sudol, M. 1995. Proc Natl Acad Sci U S A. 92: 7819-23. PMID: 7644498
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. | Pirozzi, G., et al. 1997. J Biol Chem. 272: 14611-6. PMID: 9169421
- Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. | Chen, HI., et al. 1997. J Biol Chem. 272: 17070-7. PMID: 9202023
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WBP2 Antibody (D-12) | sc-514247 | 200 µg/ml | $316.00 | |||
WBP2 Antibody (D-12): m-IgGλ BP-HRP Bundle | sc-524663 | 200 µg Ab, 40 µg BP | $354.00 | |||
WBP2 Antibody (D-12) AC | sc-514247 AC | 500 µg/ml, 25% agarose | $416.00 | |||
WBP2 Antibody (D-12) HRP | sc-514247 HRP | 200 µg/ml | $316.00 | |||
WBP2 Antibody (D-12) FITC | sc-514247 FITC | 200 µg/ml | $330.00 | |||
WBP2 Antibody (D-12) PE | sc-514247 PE | 200 µg/ml | $343.00 | |||
WBP2 Antibody (D-12) Alexa Fluor® 488 | sc-514247 AF488 | 200 µg/ml | $357.00 | |||
WBP2 Antibody (D-12) Alexa Fluor® 546 | sc-514247 AF546 | 200 µg/ml | $357.00 | |||
WBP2 Antibody (D-12) Alexa Fluor® 594 | sc-514247 AF594 | 200 µg/ml | $357.00 | |||
WBP2 Antibody (D-12) Alexa Fluor® 647 | sc-514247 AF647 | 200 µg/ml | $357.00 | |||
WBP2 Antibody (D-12) Alexa Fluor® 680 | sc-514247 AF680 | 200 µg/ml | $357.00 | |||
WBP2 Antibody (D-12) Alexa Fluor® 790 | sc-514247 AF790 | 200 µg/ml | $357.00 | |||
WBP2 (D-12) Neutralizing Peptide | sc-514247 P | 100 µg/0.5 ml | $68.00 |