WAVE2 Antibody (D-12): sc-515730

WAVE2 Antibody (D-12) is a mouse monoclonal IgG1 light chain antibody that detects WAVE2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WAVE2, a member of the WAVE protein family, plays a crucial role in actin polymerization and cytoskeletal dynamics, which are essential for various cellular processes, including cell migration, shape maintenance, and signal transduction. WAVE2 is primarily expressed in peripheral blood leukocytes, where WAVE2 is involved in the regulation of membrane ruffling and the formation of actin filament clusters in response to GTP binding and Rac activation. WAVE2 interacts with the Arp2/3 complex, facilitating the nucleation of new actin filaments and thereby promoting the reorganization of the actin cytoskeleton. Proper functioning of WAVE2 is vital for immune responses and cellular motility, making WAVE2 a significant target for research in cell biology and immunology. Anti-WAVE2 antibody (D-12) is an invaluable tool for studying the intricate mechanisms of actin dynamics and their implications in health and disease.

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WAVE2 Antibody (D-12) References:

1. Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.  |  Leng, Y., et al. 2005. Proc Natl Acad Sci U S A. 102: 1098-103. PMID: 15657136
2. A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages.  |  Kheir, WA., et al. 2005. J Cell Sci. 118: 5369-79. PMID: 16280551
3. Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity.  |  Danson, CM., et al. 2007. J Cell Sci. 120: 4144-54. PMID: 18032787
4. WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes.  |  Sun, SC., et al. 2011. Cell Cycle. 10: 1853-60. PMID: 21543895
5. MiR-146a activates WAVE2 expression and enhances phagocytosis in lipopolysaccharide-stimulated RAW264.7 macrophages.  |  Cao, Z., et al. 2015. Am J Transl Res. 7: 1467-74. PMID: 26396677
6. The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.  |  Sekino, S., et al. 2015. Cell Commun Signal. 13: 41. PMID: 26428302
7. WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge.  |  Tang, Q., et al. 2020. Mol Biol Cell. 31: 2168-2178. PMID: 32697617
8. Rac1/Wave2/Arp3 Pathway Mediates Rat Blood-Brain Barrier Dysfunction under Simulated Microgravity Based on Proteomics Strategy.  |  Yan, R., et al. 2021. Int J Mol Sci. 22: PMID: 34068233
9. SKAP2 is downregulated in the villous tissues of patients with missed abortion and regulates growth and migration in trophoblasts through the WAVE2-ARP2/3 signaling pathway.  |  Jin, X., et al. 2022. Placenta. 128: 100-111. PMID: 36126383
10. WAVE1 and WAVE2 facilitate human papillomavirus-driven actin polymerization during cellular entry.  |  Fernandez, DJ., et al. 2024. bioRxiv.. PMID: 39553927

The preferred WAVE2 antibody is WAVE2 Antibody (C-6): sc-373889.