Visual Arrestin Antibody (PDS-1): sc-32744

Visual Arrestin Antibody (PDS-1) is a mouse monoclonal IgG1 antibody engineered to detect Visual Arrestin, also known as Arrestin 1, retinal S-antigen, or S-Arrestin, across multiple species including human, mouse, rat, and porcine. Anti-Visual Arrestin antibody (PDS-1) is raised against porcine Visual Arrestin and is ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Visual Arrestin is primarily localized in the outer segments of retinal photoreceptor cells, where it plays a crucial role in the phototransduction pathway by binding to phosphorylated rhodopsin. This binding effectively terminates the light signal, preventing continuous activation of G protein-coupled receptors and ensuring precise visual signal regulation. The specific cellular localization of Visual Arrestin is essential for maintaining accurate visual perception and preventing signal desensitization. Additionally, Visual Arrestin is expressed in the pineal gland, where it contributes to the regulation of circadian rhythms. The strategic placement of Visual Arrestin within these cellular compartments highlights its importance in maintaining cellular homeostasis and proper visual function. Visual Arrestin (PDS-1) antibody facilitates research into visual signal transduction, retinal diseases, and autoimmune conditions such as uveoretinitis.

The preferred β-Arrestin-2 antibody is β-Arrestin-2 Antibody (H-9): sc-13140.