DUSP22 Antibody (9J2): sc-135602
- DUSP22 Antibody (9J2) is a mouse monoclonal IgG2a κ DUSP22 antibody provided at 100 µg/ml
- raised against recombinant DUSP22 protein of human origin
- recommended for detection of DUSP22 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DUSP22 Antibody (9J2). This work is in progress.
DUSP22 Antibody (9J2) is a mouse monoclonal IgG2a kappa light chain antibody that detects DUSP22 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DUSP22 antibody (9J2) is available as a non-conjugated format. DUSP22 plays a crucial role in regulating cellular signaling pathways by acting as a dual specificity phosphatase, which selectively dephosphorylates both phosphothreonine and phosphotyrosine residues on mitogen-activated protein kinases (MAPKs). This function helps modulate MAPK superfamily members′ activity, including ERK2 and JNK, thereby influencing various physiological processes such as cell proliferation, differentiation, and response to stress. DUSP22 is predominantly expressed in thymus, where DUSP22 is essential for T cell development, but DUSP22 is also found in monocytes and lymphocytes, highlighting DUSP22′s importance in immune responses. By regulating MAPK signaling, DUSP22 contributes to cellular homeostasis maintenance and prevention of pathological conditions, making DUSP22 a significant target for research in cancer and other diseases.
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DUSP22 Antibody (9J2) References:
- Dual specificity phosphatases: a gene family for control of MAP kinase function. | Camps, M., et al. 2000. FASEB J. 14: 6-16. PMID: 10627275
- Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. | Shen, Y., et al. 2001. Proc Natl Acad Sci U S A. 98: 13613-8. PMID: 11717427
- Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR). | Alonso, A., et al. 2002. J Biol Chem. 277: 5524-8. PMID: 11733513
- VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. | Alonso, A., et al. 2004. J Biol Chem. 279: 32586-91. PMID: 15138252
- The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. | Alonso, A., et al. 2004. J Biol Chem. 279: 35768-74. PMID: 15201283
- An emerging family of dual specificity MAP kinase phosphatases. | Keyse, SM. 1995. Biochim Biophys Acta. 1265: 152-60. PMID: 7696343
- Functional studies of dual-specificity phosphatases. | Sun, H. 1998. Methods Mol Biol. 84: 307-18. PMID: 9666459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DUSP22 Antibody (9J2) | sc-135602 | 100 µg/ml | $333.00 |