VGF Antibody (B-6): sc-515482
- VGF Antibody (B-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 591-610 at the C-terminus of VGF of rat origin
- recommended for detection of VGF of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for VGF Antibody (B-6) for WB applications. This reagent is now offered in a bundle with VGF Antibody (B-6) (see ordering information below).
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VGF Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects VGF in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-VGF antibody (B-6) recognizes VGF, a neuropeptide crucial for neuronal differentiation and survival, particularly in the peripheral nervous system and central nervous system. VGF (B-6) antibody detects VGF predominantly expressed in the adult hypothalamus, where VGF plays a vital role in regulating energy expenditure and body weight, making VGF significant for understanding metabolic disorders. VGF is synthesized and secreted by neurons and notably upregulated by nerve growth factor in the PC12 cell line, indicating VGF′s involvement in neurotrophic signaling. Additionally, VGF expression is rapidly induced by various stimuli, including injury, circadian rhythms, and neuronal activity, highlighting VGF′s dynamic role in the nervous system′s response to environmental changes. VGF′s ability to interact with other proteins involved in energy homeostasis further underscores VGF′s importance in neurobiology and potential implications in therapeutic strategies for obesity and related conditions.
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VGF Antibody (B-6) References:
- VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers. | Ferri, GL., et al. 2011. J Chem Neuroanat. 42: 249-61. PMID: 21621608
- VGF function in depression and antidepressant efficacy. | Jiang, C., et al. 2018. Mol Psychiatry. 23: 1632-1642. PMID: 29158577
- Glutamatergic dysfunction is associated with phenotypes of VGF-overexpressing mice. | Mizoguchi, T., et al. 2022. Exp Brain Res. 240: 2051-2060. PMID: 35587282
- Low VGF is associated with executive dysfunction in patients with major depressive disorder. | Ye, Q., et al. 2022. J Psychiatr Res. 152: 182-186. PMID: 35738161
- VGF nerve growth factor inducible has the potential to protect pancreatic β-cells. | Hirakida, H., et al. 2023. J Endocrinol. 257: PMID: 36988989
- Associations of VGF with Neuropathologies and Cognitive Health in Older Adults. | Yu, L., et al. 2023. Ann Neurol. 94: 232-244. PMID: 37177846
- Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis. | Dai, W., et al. 2023. J Exp Clin Cancer Res. 42: 329. PMID: 38041128
- The upregulation of VGF enhances the progression of oral squamous carcinoma. | Chou, CH., et al. 2024. Cancer Cell Int. 24: 115. PMID: 38528565
- Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis. | Wu, Z., et al. 2024. Cell Commun Signal. 22: 313. PMID: 38844957
- Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops. | Ouyang, S., et al. 2024. Adv Sci (Weinh). 11: e2407967. PMID: 39422674
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VGF Antibody (B-6) | sc-515482 | 200 µg/ml | $322.00 | |||
VGF Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-541060 | 200 µg Ab; 10 µg BP | $361.00 | |||
VGF (B-6) Neutralizing Peptide | sc-515482 P | 100 µg/0.5 ml | $69.00 |