vezatin Antibody (A-3): sc-271369

Vezatin Antibody (A-3) is a mouse monoclonal IgG2b antibody that detects vezatin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Vezatin is a crucial single transmembrane domain protein that plays a significant role in cell adhesion by localizing at adherens junctions, which are essential for maintaining tissue integrity and facilitating communication between cells. Anti-vezatin antibody (A-3) is particularly useful for studying vezatin′s concentration in the fibrillar links that connect the bases of adjacent stereocilia in sensory hair cells. The proper positioning of these stereocilia is vital for auditory function, as any disruption can lead to hearing impairments. Vezatin interacts with actin filamentous networks and anchors myosin VIIA to cadherin complexes, thereby enhancing cell-cell adhesion and influencing cadherin-based signaling pathways. The recruitment of vezatin to adherens junctions is mediated by the C-terminal region of alpha-catenin, highlighting vezatin′s role in the structural organization of cell junctions. The loss of functional vezatin-myosin VIIA complexes can result in the disorganization of stereocilia, as observed in Myo7a-/- animal models, underscoring vezatin′s importance in cellular architecture and function. Vezatin monoclonal antibody (A-3) serves as an invaluable tool for researchers studying cell adhesion mechanisms and their implications in developmental biology and disease.

The preferred vezatin antibody is vezatin Antibody (B-1): sc-271347.