VEGF Antibody (JH121): sc-57496

VEGF Antibody (JH121) is a mouse monoclonal IgG1 kappa light chain antibody that detects vascular endothelial growth factor (VEGF) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). VEGF Antibody (JH121) is available in a non-conjugated form, allowing for versatile experimental use. VEGF plays a crucial role in angiogenesis, the process of new blood vessel formation, which is vital for supplying nutrients and oxygen to tissues, particularly during development and in response to injury. VEGF dysregulation is implicated in various pathological conditions, including cancer, where VEGF promotes tumor growth and metastasis by enhancing blood supply to the tumor microenvironment. VEGF exists as a dimeric glycoprotein and exhibits structural similarities to platelet-derived growth factor (PDGF), with multiple isoforms generated through alternative mRNA splicing. VEGF expression is tightly regulated, and VEGF mRNA is often found in primary tumors, indicating VEGF′s potential as a therapeutic target. Additionally, VEGF interacts with high-affinity receptors such as Flt, a member of the PDGF receptor family, which mediates VEGF′s angiogenic effects. anti-VEGF antibody (JH121) serves as an essential tool for researchers studying angiogenesis and its implications in various diseases.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VEGF Antibody (JH121) has 86 citations in a variety of scientific publications.

Primary antibodies like Anti-VEGF Antibody (JH121) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VEGF Antibody (JH121) Specifications

Alternate Product Name: VEGF

Product Clone Name: JH121

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: VEGF

Epitope Species: human

Product Reactivity/Detection: all forms of VEGF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 86 citations in various scientific publications

Available Conjugates/Forms for VEGF Antibody (JH121): N/A

The preferred VEGF antibody is VEGF Antibody (C-1): sc-7269.