VEGF Antibody (F-5): sc-365578

VEGF Antibody (F-5) is a mouse monoclonal IgM kappa antibody that detects vascular endothelial growth factor (VEGF) from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VEGF Antibody (F-5) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. VEGF plays a crucial role in angiogenesis, the process of new blood vessel formation, which is vital for normal physiological processes such as wound healing and embryonic development. Dysregulation of VEGF is implicated in pathological conditions, including cancer, where VEGF promotes tumor growth and metastasis by enhancing blood supply to the tumor microenvironment. VEGF exists in several splice variants, including VEGF189, VEGF165, and VEGF121, each with distinct biological activities and regulatory mechanisms. These variants allow for a finely tuned response to hypoxic conditions, making VEGF a key player in both normal and pathological angiogenesis. VEGF interacts with specific receptors, such as Flt-1 (VEGFR-1) and KDR (VEGFR-2), which mediate effects on endothelial cells, further underscoring VEGF′s importance in vascular biology. anti-VEGF antibody (F-5) enables researchers to gain insights into VEGF′s role in various biological contexts, enhancing understanding of VEGF function in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VEGF Antibody (F-5) has 18 citations in a variety of scientific publications.

Primary antibodies like Anti-VEGF Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VEGF Antibody (F-5) Specifications

Alternate Product Name: VEGF

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: VEGF-A

Epitope Species: human

Product Reactivity/Detection: the 189, 165 and 121 amino acid splice variants of VEGF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 18 citations in various scientific publications

Available Conjugates/Forms for VEGF Antibody (F-5): P: Blocking Peptide

The preferred VEGF antibody is VEGF Antibody (C-1): sc-7269.