VE-cadherin Antibody (F-8): sc-9989
- VE-cadherin Antibody (F-8) is a mouse monoclonal IgG1 κ VE-cadherin antibody, cited in 411 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 768-784 at the C-terminus of VE-cadherin of human origin
- VE-cadherin Antibody (F-8) is recommended for detection of VE-cadherin of mouse, rat and human origin by WB, IP, IF, FCM and ELISA; also reactive with additional species, including porcine
- Anti-VE-cadherin Antibody (F-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of VE-cadherin (F-8): sc-9989.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for VE-cadherin Antibody (F-8) for WB applications. This reagent is now offered in a bundle with VE-cadherin Antibody (F-8) (see ordering information below).
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VE-cadherin Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody designed to target VE-cadherin, also known as CDH5 or Cadherin-5, a crucial calcium-dependent adhesion molecule involved in endothelial cell-cell junctions. Anti-VE-cadherin antibody (F-8) recognizes a precise epitope mapping between amino acids 768-784 at the C-terminus of human VE-cadherin, ensuring accurate detection and binding. VE-cadherin plays a vital role in maintaining vascular integrity, regulating vascular permeability, and facilitating angiogenesis, making VE-cadherin essential for vascular development and function. By mediating cell-cell adhesion, VE-cadherin is pivotal in preserving tissue structure and morphogenesis, and VE-cadherin interaction with cytoplasmic proteins like β-catenin is critical for regulating function. VE-cadherin monoclonal antibody (F-8) detects VE-cadherin in mouse, rat, human, and additional species such as porcine through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, anti-VE-cadherin antibody (F-8) is recommended for researchers studying the mechanisms underlying vascular cohesion and endothelial function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VE-cadherin Antibody (F-8) References:
- Genomic organization and chromosomal mapping of the mouse P-cadherin gene. | Hatta, M., et al. 1991. Nucleic Acids Res. 19: 4437-41. PMID: 1886768
- The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | Takeichi, M. 1988. Development. 102: 639-55. PMID: 3048970
- Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. | Breviario, F., et al. 1995. Arterioscler Thromb Vasc Biol. 15: 1229-39. PMID: 7627717
- Desmosomal cadherins: another growing multigene family of adhesion molecules. | Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
- Cadherins and catenins: interactions and functions in embryonic development. | Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
- Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. | Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
- Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. | Hinck, L., et al. 1994. J Cell Biol. 125: 1327-40. PMID: 8207061
- Morphogenetic roles of classic cadherins. | Takeichi, M. 1995. Curr Opin Cell Biol. 7: 619-27. PMID: 8573335
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VE-cadherin Antibody (F-8) | sc-9989 | 200 µg/ml | $316.00 | |||
VE-cadherin Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-525455 | 200 µg Ab; 10 µg BP | $354.00 | |||
VE-cadherin Antibody (F-8) AC | sc-9989 AC | 500 µg/ml, 25% agarose | $416.00 | |||
VE-cadherin Antibody (F-8) HRP | sc-9989 HRP | 200 µg/ml | $316.00 | |||
VE-cadherin Antibody (F-8) FITC | sc-9989 FITC | 200 µg/ml | $330.00 | |||
VE-cadherin Antibody (F-8) PE | sc-9989 PE | 200 µg/ml | $343.00 | |||
VE-cadherin Antibody (F-8) Alexa Fluor® 488 | sc-9989 AF488 | 200 µg/ml | $357.00 | |||
VE-cadherin Antibody (F-8) Alexa Fluor® 546 | sc-9989 AF546 | 200 µg/ml | $357.00 | |||
VE-cadherin Antibody (F-8) Alexa Fluor® 594 | sc-9989 AF594 | 200 µg/ml | $357.00 | |||
VE-cadherin Antibody (F-8) Alexa Fluor® 647 | sc-9989 AF647 | 200 µg/ml | $357.00 | |||
VE-cadherin Antibody (F-8) Alexa Fluor® 680 | sc-9989 AF680 | 200 µg/ml | $357.00 | |||
VE-cadherin Antibody (F-8) Alexa Fluor® 790 | sc-9989 AF790 | 200 µg/ml | $357.00 | |||
VE-cadherin (F-8) Neutralizing Peptide | sc-9989 P | 100 µg/0.5 ml | $68.00 |