VE-cadherin-2 Antibody (F-4): sc-515467
- VE-cadherin-2 Antibody (F-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 452-593 mapping within an internal region of VE-cadherin-2 of mouse origin
- Anti-VE-cadherin-2 Antibody (F-4) is recommended for detection of VE-cadherin-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-VE-cadherin-2 Antibody (F-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VE-cadherin-2 Antibody (F-4) for WB applications. These reagents are now offered in bundles with VE-cadherin-2 Antibody (F-4) (see ordering information below).
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VE-cadherin-2 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects VE-cadherin-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-VE-cadherin-2 antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VE-cadherin-2, also known as protocadherin 12 (PCDH12), is a 1,184 amino acid single-pass type I membrane protein predominantly expressed in vascularized tissues such as the heart and placenta. VE-cadherin-2 plays a crucial role in mediating cell-cell adhesion, which is essential for maintaining tissue integrity and facilitating morphogenetic processes. The extracellular domain of VE-cadherin-2 contains five homologous repeats that contribute to binding specificity, while the short intracellular domain interacts with cytoplasmic proteins like β-catenin, thereby regulating cadherin function. VE-cadherin-2′s role in promoting homotypic calcium-dependent aggregation and adhesion at intercellular junctions underscores significance in vascular development and tissue organization, making VE-cadherin-2 a valuable target for research in cell biology and developmental processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VE-cadherin-2 Antibody (F-4) References:
- cDNA cloning, chromosomal mapping, and expression analysis of human VE-Cadherin-2. | Ludwig, D., et al. 2000. Mamm Genome. 11: 1030-3. PMID: 11063261
- Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells. | Rampon, C., et al. 2005. Exp Cell Res. 302: 48-60. PMID: 15541725
- Endothelial cadherins and tumor angiogenesis. | Cavallaro, U., et al. 2006. Exp Cell Res. 312: 659-67. PMID: 16256984
- Tracing the glycogen cells with protocadherin 12 during mouse placenta development. | Bouillot, S., et al. 2006. Placenta. 27: 882-8. PMID: 16269175
- Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. | Son, BR., et al. 2006. Stem Cells. 24: 1254-64. PMID: 16410389
- Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. | Turowski, P., et al. 2008. J Cell Sci. 121: 29-37. PMID: 18096689
- Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta. | Rampon, C., et al. 2008. Physiol Genomics. 34: 193-204. PMID: 18477666
- Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. | Gregório, SP., et al. 2009. Psychiatry Res. 165: 1-9. PMID: 19054571
- Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells. | Telo', P., et al. 1998. J Biol Chem. 273: 17565-72. PMID: 9651350
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VE-cadherin-2 Antibody (F-4) | sc-515467 | 200 µg/ml | $322.00 | |||
VE-cadherin-2 Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-531383 | 200 µg Ab; 10 µg BP | $361.00 | |||
VE-cadherin-2 Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-525059 | 200 µg Ab, 40 µg BP | $361.00 | |||
VE-cadherin-2 Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-544517 | 200 µg Ab; 20 µg BP | $361.00 | |||
VE-cadherin-2 Antibody (F-4) AC | sc-515467 AC | 500 µg/ml, 25% agarose | $424.00 | |||
VE-cadherin-2 Antibody (F-4) HRP | sc-515467 HRP | 200 µg/ml | $322.00 | |||
VE-cadherin-2 Antibody (F-4) FITC | sc-515467 FITC | 200 µg/ml | $336.00 | |||
VE-cadherin-2 Antibody (F-4) PE | sc-515467 PE | 200 µg/ml | $349.00 | |||
VE-cadherin-2 Antibody (F-4) Alexa Fluor® 488 | sc-515467 AF488 | 200 µg/ml | $364.00 | |||
VE-cadherin-2 Antibody (F-4) Alexa Fluor® 546 | sc-515467 AF546 | 200 µg/ml | $364.00 | |||
VE-cadherin-2 Antibody (F-4) Alexa Fluor® 594 | sc-515467 AF594 | 200 µg/ml | $364.00 | |||
VE-cadherin-2 Antibody (F-4) Alexa Fluor® 647 | sc-515467 AF647 | 200 µg/ml | $364.00 | |||
VE-cadherin-2 Antibody (F-4) Alexa Fluor® 680 | sc-515467 AF680 | 200 µg/ml | $364.00 | |||
VE-cadherin-2 Antibody (F-4) Alexa Fluor® 790 | sc-515467 AF790 | 200 µg/ml | $364.00 |