Vitamin D Receptor/VDR Antibody (D-6): sc-13133
- Vitamin D Receptor/VDR Antibody (D-6) is a mouse monoclonal IgG2a κ Vitamin D Receptor/VDR antibody, cited in 437 publications, provided at 200 µg/ml
- raised against amino acids 344-424 of VDR of human origin
- Vitamin D Receptor/VDR Antibody (D-6) is recommended for detection of VDR of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-Vitamin D Receptor/VDR Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-13133 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Vitamin D Receptor/VDR Antibody (D-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Vitamin D Receptor/VDR Antibody (D-6) (see ordering information below).
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SEE ALSO...
VDR Antibody (D-6) is a mouse monoclonal IgG2a kappa light chain antibody raised against amino acids 344-424 of human Vitamin D Receptor (VDR), also known as NR1I1. VDR is a nuclear hormone receptor and transcription factor that mediates the effects of 1,25-dihydroxyvitamin D3, the active form of vitamin D. Upon ligand binding, VDR forms heterodimers with the retinoid X receptor (RXR) and binds to vitamin D response elements (VDREs) in DNA, regulating the expression of genes involved in calcium and phosphate homeostasis, cell proliferation, differentiation, and immune responses. The function of VDR is crucial for maintaining bone health by promoting calcium absorption and bone mineralization, and also plays a role in modulating the immune system and inhibiting the proliferation of cancer cells in tissues such as the skin, colon, and breast. Dysregulation of VDR signaling has been implicated in various diseases, including osteoporosis, autoimmune disorders, and certain cancers. VDR monoclonal antibody (D-6) reacts with mouse, rat, and human VDR and is suitable for applications such as WB, IP, IF, and IHCP. By targeting VDR, this specific antibody aids researchers in studying the molecular mechanisms of vitamin D signaling and its impact on health and disease. Understanding VDR function is important for developing therapeutic strategies against conditions resulting from vitamin D deficiency or impaired VDR activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Vitamin D Receptor/VDR Antibody (D-6) References:
- Vitamin D-mediated gene expression. | Lowe, KE., et al. 1992. Crit Rev Eukaryot Gene Expr. 2: 65-109. PMID: 1543898
- Vitamin D and prostate cancer. | Feldman, D., et al. 1995. Adv Exp Med Biol. 375: 53-63. PMID: 7645428
- Genomic actions of 1,25-dihydroxyvitamin D3. | Whitfield, GK., et al. 1995. J Nutr. 125: 1690S-1694S. PMID: 7782928
- Vitamin D receptors in breast cancer cells. | Buras, RR., et al. 1994. Breast Cancer Res Treat. 31: 191-202. PMID: 7881099
- Role of vitamin D, its metabolites, and analogs in the management of osteoporosis. | Bikle, DD. 1994. Rheum Dis Clin North Am. 20: 759-75. PMID: 7984788
- Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases. | Studzinski, GP., et al. 1993. Crit Rev Eukaryot Gene Expr. 3: 279-312. PMID: 8286848
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vitamin D Receptor/VDR Antibody (D-6) | sc-13133 | 200 µg/ml | $322.00 | |||
Vitamin D Receptor/VDR Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-525466 | 200 µg Ab; 10 µg BP | $361.00 | |||
Vitamin D Receptor/VDR Antibody (D-6): m-IgG2a BP-HRP Bundle | sc-546272 | 200 µg Ab; 10 µg BP | $361.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) X | sc-13133 X | 200 µg/0.1 ml | $322.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) AC | sc-13133 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) HRP | sc-13133 HRP | 200 µg/ml | $322.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) FITC | sc-13133 FITC | 200 µg/ml | $336.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) PE | sc-13133 PE | 200 µg/ml | $349.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) Alexa Fluor® 488 | sc-13133 AF488 | 200 µg/ml | $364.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) Alexa Fluor® 546 | sc-13133 AF546 | 200 µg/ml | $364.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) Alexa Fluor® 594 | sc-13133 AF594 | 200 µg/ml | $364.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) Alexa Fluor® 647 | sc-13133 AF647 | 200 µg/ml | $364.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) Alexa Fluor® 680 | sc-13133 AF680 | 200 µg/ml | $364.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) Alexa Fluor® 790 | sc-13133 AF790 | 200 µg/ml | $364.00 | |||
Vitamin D Receptor/VDR Antibody (D-6) B | sc-13133 B | 200 µg/ml | $326.00 |