VDR Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Binds directly to VDR, promoting its activation | ||||||
EB 1089 | 134404-52-7 | sc-358831A sc-358831 sc-358831B | 500 µg 1 mg 5 mg | $158.00 $208.00 $923.00 | 4 | |
EB 1089 (CAS 134404-52-7) is a synthetic analog of calcitriol designed to activate the Vitamin D Receptor (VDR). It binds to VDR, inducing a structural shift that allows the receptor to form a heterodimer with retinoid X receptors (RXRs). This complex then engages with vitamin D response elements (VDREs) in DNA, initiating transcription of specific genes. Known for its high affinity for VDR, EB 1089 is commonly used in research to study VDR activation's biochemical and cellular impacts. | ||||||
25-Hydroxyvitamin D3 | 19356-17-3 | sc-288574A sc-288574 sc-288574B sc-288574C sc-288574D sc-288574E | 1 mg 5 mg 25 mg 500 mg 1 g 10 g | $106.00 $365.00 $773.00 $1324.00 $2266.00 $11830.00 | 13 | |
25-Hydroxyvitamin D3 (CAS 19356-17-3) is a vitamin D3 metabolite that acts as a precursor to calcitriol, the active form with higher VDR affinity. It binds to VDR, undergoes a structural change, and forms a heterodimer with RXRs. This complex engages with VDREs in DNA to initiate gene transcription. It's a key compound for studying VDR activation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol (CAS 67-97-0), also known as Vitamin D3, is a prohormone that serves as a precursor to the active form, calcitriol. It undergoes hydroxylation in the liver and kidneys to become an effective VDR activator. Once converted, it binds to VDR, triggering a conformational change that enables the receptor to form a heterodimer with retinoid X receptors (RXRs). This complex interacts with vitamin D response elements (VDREs) in DNA, initiating transcription of specific genes. | ||||||
Ercalcitriol-d6 | 216244-04-1 | sc-353279 | 1 mg | $2352.00 | ||
Ercalcitriol-d6 (CAS 216244-04-1) is a deuterated form of ercalcitriol, which itself is an analog of calcitriol. It effectively activates the Vitamin D Receptor (VDR) by binding to it. This binding leads to a structural alteration in VDR, allowing it to heterodimerize with retinoid X receptors (RXRs). The resulting complex interacts with vitamin D response elements (VDREs) in DNA, initiating the transcription of specific genes involved in various cellular processes. | ||||||
Vitamin D2, 1a-Hydroxy- | 54573-75-0 | sc-205886 | 1 mg | $60.00 | ||
1α-Hydroxyvitamin D2 (CAS 54573-75-0) is a synthetic analog of the naturally occurring vitamin D2. It activates the Vitamin D Receptor (VDR) by binding directly to it. This interaction induces a conformational change in the VDR, enabling it to form a heterodimer with retinoid X receptors (RXRs). The resulting complex targets vitamin D response elements (VDREs) within DNA, initiating the transcription of specific genes crucial for cellular processes like calcium homeostasis. | ||||||
Alfacalcidol-d7 | sc-217598 | 10 mg | $19700.00 | |||
Alfacalcidol-d7 is a deuterated variant of alfacalcidol, a prodrug that is metabolized to calcitriol, the active form that binds to the Vitamin D Receptor (VDR). Upon binding, the VDR undergoes a conformational shift that allows it to heterodimerize with retinoid X receptors (RXRs). This complex interacts with vitamin D response elements (VDREs) in the DNA, initiating the transcription of target genes involved in various cellular activities such as calcium regulation. | ||||||