VASP Antibody (D-11): sc-376226
- VASP Antibody (D-11) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 353-385 near the C-terminus of VASP of human origin
- recommended for detection of VASP of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for VASP Antibody (D-11) for WB applications. This reagent is now offered in a bundle with VASP Antibody (D-11) (see ordering information below).
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VASP Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects VASP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). VASP, or vaso-dilator-stimulated phosphoprotein, plays a crucial role in maintaining cellular architecture by interacting with actin filaments, which is essential for various cellular processes including cell migration, adhesion, and shape maintenance. VASP is primarily localized to focal adhesions and microfilaments, where VASP contributes to the dynamic reorganization of the cytoskeleton in response to extracellular signals. VASP undergoes post-translational modifications, particularly phosphorylation at Serine residue 157, which regulates VASP activity and localization. This phosphorylation is mediated by cAMP and cGMP-dependent kinases, highlighting VASP′s involvement in signaling pathways that govern cytoskeletal dynamics. Given VASP′s high expression in human platelets and functional similarities to WASP, VASP is not only vital for cytoskeletal organization but also plays a significant role in processes related to thrombosis and immune responses, making anti-VASP antibody (D-11) an invaluable tool for researchers studying these critical biological functions.
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VASP Antibody (D-11) References:
- Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells. | Wang, X., et al. 2007. Am J Physiol Renal Physiol. 293: F1768-76. PMID: 17913834
- Role of Ena/VASP proteins in homeostasis and disease. | Pula, G. and Krause, M. 2008. Handb Exp Pharmacol. 39-65. PMID: 18491048
- Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance. | Kang, YM., et al. 2017. Diabetes Metab J. 41: 89-95. PMID: 28447436
- VASP Regulates NK Cell Lytic Granule Convergence. | Wilton, KM. and Billadeau, DD. 2018. J Immunol. 201: 2899-2909. PMID: 30282752
- VASP-mediated actin dynamics activate and recruit a filopodia myosin. | Arthur, AL., et al. 2021. Elife. 10: PMID: 34042588
- VASP boosts protrusive activity of macroendocytic cups and drives phagosome rocketing after internalization. | Körber, S. and Faix, J. 2022. Eur J Cell Biol. 101: 151200. PMID: 35101769
- VASP localization to lipid bilayers induces polymerization driven actin bundle formation. | Nast-Kolb, T., et al. 2022. Mol Biol Cell. 33: ar91. PMID: 35830600
- PtdIns(3,4)P2, Lamellipodin, and VASP coordinate actin dynamics during phagocytosis in macrophages. | Montaño-Rendón, F., et al. 2022. J Cell Biol. 221: PMID: 36165850
- Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. | Cakir, Z., et al. 2023. Mol Cell Proteomics. 22: 100541. PMID: 37019383
- PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells. | Wang, C., et al. 2023. Exp Cell Res. 433: 113823. PMID: 37890607
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VASP Antibody (D-11) | sc-376226 | 200 µg/ml | $322.00 | |||
VASP Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-540532 | 200 µg Ab; 10 µg BP | $361.00 | |||
VASP (D-11) Neutralizing Peptide | sc-376226 P | 100 µg/0.5 ml | $69.00 |