VAMP-2 Antibody (3E5): sc-69706

VAMP-2 Antibody (3E5) is a mouse monoclonal IgG1 antibody that detects VAMP-2 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). Anti-VAMP-2 antibody (3E5) is available in a non-conjugated form, allowing for versatile applications in research. VAMP-2, also known as synaptobrevin-2, plays a crucial role in synaptic vesicle exocytosis, essential for neurotransmitter release in neurons. VAMP-2 is primarily located in synaptic vesicles of presynaptic neurons, where VAMP-2 facilitates vesicle fusion with the plasma membrane, enabling neurotransmitter release into the synaptic cleft. Proper functioning of VAMP-2 is vital for effective communication between neurons, and dysregulation can lead to various neurological disorders. VAMP-2 interacts with several key proteins involved in exocytosis, including syntaxins and SNAPs, forming a complex critical for membrane fusion. Using VAMP-2 monoclonal antibody (3E5) enables valuable insights into synaptic transmission mechanisms and VAMP-2′s role in cellular communication.

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VAMP-2 Antibody (3E5) References:

1. CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.  |  Lam, M., et al. 2022. Nat Commun. 13: 5583. PMID: 36151203
2. VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy.  |  Liu, H., et al. 2024. Dev Cell. 59: 2005-2016.e4. PMID: 38810653
3. VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.  |  Wang, C., et al. 2024. Nat Cell Biol. 26: 1287-1295. PMID: 38951706
4. VAMP2 regulates phase separation of α-synuclein.  |  Agarwal, A., et al. 2024. Nat Cell Biol. 26: 1296-1308. PMID: 38951707
5. The syntaxin family of vesicular transport receptors.  |  Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
6. Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.  |  Edelmann, L., et al. 1995. EMBO J. 14: 224-31. PMID: 7835333
7. Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site.  |  McMahon, HT. and Südhof, TC. 1995. J Biol Chem. 270: 2213-7. PMID: 7836452
8. Exocytosis relating proteins in the nervous system.  |  Yamaguchi, K. and Akagawa, K. 1994. Neurosci Res. 20: 289-92. PMID: 7870381
9. Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.  |  Hayashi, T., et al. 1994. EMBO J. 13: 5051-61. PMID: 7957071
10. A role for synaptotagmin (p65) in regulated exocytosis.  |  Elferink, LA., et al. 1993. Cell. 72: 153-9. PMID: 8422678
11. Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis.  |  Barnard, RJ., et al. 1997. J Cell Biol. 139: 875-83. PMID: 9362506
12. Structural organization of the synaptic exocytosis core complex.  |  Lin, RC. and Scheller, RH. 1997. Neuron. 19: 1087-94. PMID: 9390521

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VAMP-2 Antibody (3E5) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-VAMP-2 Antibody (3E5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VAMP-2 Antibody (3E5) Specifications

Alternate Product Name: VAMP-2

Product Clone Name: 3E5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1-89

Epitope Target: VAMP-2

Epitope Species: human

Product Reactivity/Detection: VAMP-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for VAMP-2 Antibody (3E5): N/A