VAMP-1/2 Antibody (3H3117): sc-73249
- VAMP-1/2 Antibody (3H3117) is a mouse monoclonal IgM κ, cited in 2 publications, provided at 200 µg/ml
- raised against synaptic vesicle-containing fractions of immunoprecipitated human brain homogenate
- recommended for detection of VAMP-1 (amino acids 1-118) and VAMP-2 (amino acids 33-96) of mouse, rat and human origin by WB, IP and IF
- m-IgGκ BP-HRP is the preferred secondary detection reagent for VAMP-1/2 Antibody (3H3117) for WB applications. This reagent is now offered in a bundle with VAMP-1/2 Antibody (3H3117) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
VAMP-1/2 Antibody (3H3117) is a mouse monoclonal IgM antibody that detects VAMP-1/2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). VAMP-1 and VAMP-2, also known as vesicle-associated membrane proteins, play a crucial role in the process of exocytosis, which is essential for neurotransmitter release and various cellular signaling pathways. These proteins are primarily located on the membranes of synaptic vesicles and are vital for the fusion of these vesicles with the presynaptic membrane, facilitating the release of neurotransmitters into the synaptic cleft. The interaction of VAMPs with syntaxins and SNAPs is critical for the formation of the SNARE complex, which drives membrane fusion. Disruption of this process can lead to significant neurological disorders, highlighting the importance of VAMP-1 and VAMP-2 in maintaining proper synaptic function. Anti-VAMP-1/2 antibody (3H3117) is an invaluable tool for researchers studying the mechanisms of exocytosis and its implications in various physiological and pathological conditions.
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VAMP-1/2 Antibody (3H3117) References:
- The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. | Boal, F., et al. 2004. Biochemistry. 43: 16212-23. PMID: 15610015
- Identification of the amino acid residues rendering TI-VAMP insensitive toward botulinum neurotoxin B. | Sikorra, S., et al. 2006. J Mol Biol. 357: 574-82. PMID: 16430921
- Distinct patterns of expression of two VAMP genes within the rat brain. | Trimble, WS., et al. 1990. J Neurosci. 10: 1380-7. PMID: 2329380
- Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. | Elferink, LA., et al. 1989. J Biol Chem. 264: 11061-4. PMID: 2472388
- Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems. | Elliott, M., et al. 2017. PLoS One. 12: e0185628. PMID: 28982136
- Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion. | Gaisano, HY., et al. 1994. J Biol Chem. 269: 17062-6. PMID: 7516331
- Vesicle-associated membrane protein (VAMP)/synaptobrevin-2 is associated with dense core secretory granules in PC12 neuroendocrine cells. | Papini, E., et al. 1995. J Biol Chem. 270: 1332-6. PMID: 7836399
- VAMP/synaptobrevin isoforms 1 and 2 are widely and differentially expressed in nonneuronal tissues. | Rossetto, O., et al. 1996. J Cell Biol. 132: 167-79. PMID: 8567721
- The vesicle-associated membrane protein family of proteins in rat pancreatic and parotid acinar cells. | Gaisano, HY., et al. 1996. Gastroenterology. 111: 1661-9. PMID: 8942747
- Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1). | Mandic, R., et al. 1997. Gene. 199: 173-9. PMID: 9358054
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VAMP-1/2 Antibody (3H3117) | sc-73249 | 200 µg/ml | $322.00 | |||
VAMP-1/2 Antibody (3H3117): m-IgGκ BP-HRP Bundle | sc-550736 | 200 µg Ab; 40 µg BP | $361.00 |