V-ATPase C1 Antibody (C-2): sc-376227

V-ATPase C1 Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects V-ATPase C in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). V-ATPase C plays a crucial role as an auxiliary subunit of the vacuolar-type H+-ATPase, which is essential for the acidification of eukaryotic intracellular organelles, thereby influencing numerous cellular processes such as nutrient uptake, protein sorting, and cellular signaling. The proper functioning of V-ATPase C is vital for maintaining pH homeostasis within organelles, which is critical for enzymatic activities and overall cellular health. Additionally, V-ATPase C is widely expressed across various tissues, indicating its fundamental role in cellular physiology. The gene encoding human V-ATPase C is located on chromosome 8q22.3, and V-ATPase C′s interaction with other subunits of the V-ATPase complex underscores its importance in the rotary mechanism that drives proton translocation. Anti-V-ATPase C antibody (C-2) is an invaluable tool for researchers studying the dynamics of intracellular pH regulation and the broader implications of V-ATPase function in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

V-ATPase C1 Antibody (C-2) References:

1. Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.  |  Feng, S., et al. 2009. Biochem J. 417: 195-203. PMID: 18657050
2. Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma.  |  Pérez-Sayáns, M., et al. 2010. Cancer Biol Ther. 9: 1057-64. PMID: 20404513
3. Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.  |  Feng, S., et al. 2013. Int J Biol Sci. 9: 853-62. PMID: 24155661
4. Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.  |  Cai, M., et al. 2014. PLoS One. 9: e84833. PMID: 24454753
5. Expression of ATP6V1C1 during oral carcinogenesis.  |  Oliveira Alves, MG., et al. 2016. Biotech Histochem. 91: 263-8. PMID: 26984774
6. Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.  |  McConnell, M., et al. 2017. Oncotarget. 8: 47675-47690. PMID: 28504970
7. MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.  |  Jing, F., et al. 2019. Int J Mol Sci. 20: PMID: 30781750
8. The ATPase subunit of ATP6V1C1 inhibits autophagy and enhances radiotherapy resistance in esophageal squamous cell carcinoma.  |  Yao, X., et al. 2021. Gene. 768: 145261. PMID: 33183740
9. Dominantly acting variants in ATP6V1C1 and ATP6V1B2 cause a multisystem phenotypic spectrum by altering lysosomal and/or autophagosome function.  |  Carpentieri, G., et al. 2024. HGG Adv. 5: 100349. PMID: 39210597
10. ATP6V1C1, associated with the tumor microenvironment and mTORC1 signaling pathway, is a potential diagnostic, prognostic, and therapeutic biomarker for hepatocellular carcinoma.  |  Pan, Y., et al. 2024. Discov Oncol. 15: 673. PMID: 39557733

The preferred V-ATPase C1 antibody is V-ATPase C1 Antibody (G-5): sc-271077.