V-ATPase B2 Antibody (C-9): sc-166122

V-ATPase B2 Antibody (C-9) is a mouse monoclonal IgG3 antibody that detects V-ATPase B2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). V-ATPase B2 is a crucial component of the vacuolar-type H+-ATPase complex, which plays a vital role in maintaining cellular pH and ion homeostasis by facilitating proton transport across membranes. V-ATPase B2 is predominantly located in the kidney and osteoclasts, where V-ATPase B2 is essential for bone resorption and renal acidification. Proper functioning of V-ATPase B2 is critical for normal physiological processes, as V-ATPase B2 helps regulate the acidic environment necessary for various cellular functions, including enzyme activity and metabolic processes. Notably, mutations in the gene encoding V-ATPase B2 can lead to significant health issues, including impaired bone density and renal tubular acidosis. Anti-V-ATPase B2 antibody (C-9) provides a reliable tool for researchers investigating the role of V-ATPase B2 in health and disease, enabling a deeper understanding of its function and interactions within the cellular environment.

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V-ATPase B2 Antibody (C-9) References:

1. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase.  |  Curtis, LM. and Gluck, S. 2005. Nephron Physiol. 100: p31-42. PMID: 15838183
2. Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.  |  Da Silva, N., et al. 2007. Am J Physiol Cell Physiol. 293: C199-210. PMID: 17392376
3. Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.  |  Paunescu, TG., et al. 2007. Am J Physiol Renal Physiol. 293: F1915-26. PMID: 17898041
4. Role of CFTR and ClC-5 in modulating vacuolar H+-ATPase activity in kidney proximal tubule.  |  Carraro-Lacroix, LR., et al. 2010. Cell Physiol Biochem. 26: 563-76. PMID: 21063094
5. V-ATPase promotes transforming growth factor-β-induced epithelial-mesenchymal transition of rat proximal tubular epithelial cells.  |  Cao, X., et al. 2012. Am J Physiol Renal Physiol. 302: F1121-32. PMID: 22129967
6. Interaction between V-ATPase B2 and (Pro) renin Receptors in Promoting the progression of Renal Tubulointerstitial Fibrosis.  |  Liu, Y., et al. 2016. Sci Rep. 6: 25035. PMID: 27121029
7. Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity.  |  Han, X., et al. 2022. Ecotoxicol Environ Saf. 236: 113500. PMID: 35421827
8. Overexpression of V-ATPase B2 attenuates lung injury/fibrosis by stabilizing lysosomal membrane permeabilization and increasing collagen degradation.  |  Lee, JU., et al. 2022. Exp Mol Med. 54: 662-672. PMID: 35624153
9. V-ATPase B2 promotes microglial phagocytosis of myelin debris by inactivating the MAPK signaling pathway.  |  Li, Y., et al. 2024. Neuropeptides. 106: 102436. PMID: 38733728
10. F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells.  |  Zhang, Y., et al. 2025. J Hazard Mater. 487: 137111. PMID: 39793390

The preferred V-ATPase B1/2 antibody is V-ATPase B1/2 Antibody (F-6): sc-55544.