USP42 Antibody (D-4): sc-390604
- USP42 Antibody (D-4) is a mouse monoclonal IgG1 κ USP42 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 408-531 mapping within an internal region of USP42 of human origin
- USP42 Antibody (D-4) is recommended for detection of USP42 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-USP42 Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for USP42 Antibody (D-4) for WB and IHC(P) applications. These reagents are now offered in bundles with USP42 Antibody (D-4) (see ordering information below).
USP42 Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects USP42 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). USP42 (D-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. USP42 protein, which is 1,325 amino acids long and belongs to the peptidase C19 family, plays a crucial role in the ubiquitin-proteasome pathway, a vital cellular mechanism that regulates protein degradation and turnover. This pathway is essential for maintaining cellular homeostasis, as USP42 controls various intracellular processes such as signal transduction, transcriptional activation, and cell cycle progression. By catalyzing the conversion of a ubiquitin C-terminal thioester to free ubiquitin and a thiol, USP42 helps modulate ubiquitin levels available for tagging proteins for degradation, thereby influencing numerous cellular functions. USP42 gene is located on human chromosome 7, a region associated with several genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, highlighting USP42′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
USP42 Antibody (D-4) References:
- A genomic perspective on human proteases. | Southan, C. 2001. FEBS Lett. 498: 214-8. PMID: 11412860
- Human and mouse proteases: a comparative genomic approach. | Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. | Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
- A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42. | Paulsson, K., et al. 2006. Leukemia. 20: 224-9. PMID: 16357831
- The expression of Usp42 during embryogenesis and spermatogenesis in mouse. | Kim, YK., et al. 2007. Gene Expr Patterns. 7: 143-8. PMID: 16904385
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP42 Antibody (D-4) | sc-390604 | 200 µg/ml | $316.00 | |||
USP42 Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-523599 | 200 µg Ab, 40 µg BP | $354.00 | |||
USP42 Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-533595 | 200 µg Ab; 20 µg BP | $354.00 | |||
USP42 Antibody (D-4) AC | sc-390604 AC | 500 µg/ml, 25% agarose | $416.00 | |||
USP42 Antibody (D-4) HRP | sc-390604 HRP | 200 µg/ml | $316.00 | |||
USP42 Antibody (D-4) FITC | sc-390604 FITC | 200 µg/ml | $330.00 | |||
USP42 Antibody (D-4) PE | sc-390604 PE | 200 µg/ml | $343.00 | |||
USP42 Antibody (D-4) Alexa Fluor® 488 | sc-390604 AF488 | 200 µg/ml | $357.00 | |||
USP42 Antibody (D-4) Alexa Fluor® 546 | sc-390604 AF546 | 200 µg/ml | $357.00 | |||
USP42 Antibody (D-4) Alexa Fluor® 594 | sc-390604 AF594 | 200 µg/ml | $357.00 | |||
USP42 Antibody (D-4) Alexa Fluor® 647 | sc-390604 AF647 | 200 µg/ml | $357.00 | |||
USP42 Antibody (D-4) Alexa Fluor® 680 | sc-390604 AF680 | 200 µg/ml | $357.00 | |||
USP42 Antibody (D-4) Alexa Fluor® 790 | sc-390604 AF790 | 200 µg/ml | $357.00 |