USP40 Antibody (G-8): sc-514248
- USP40 Antibody (G-8) is a mouse monoclonal IgG1 κ USP40 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 456-654 mapping within an internal region of USP40 of human origin
- USP40 Antibody (G-8) is recommended for detection of USP40 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-USP40 Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for USP40 Antibody (G-8) for WB applications. These reagents are now offered in bundles with USP40 Antibody (G-8) (see ordering information below).
USP40 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects USP40 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). USP40 Antibody (G-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. USP40, also known as ubiquitin specific peptidase 40, plays a crucial role in the ubiquitin-proteasome system, which maintains cellular homeostasis by regulating protein degradation and turnover. USP40 functions as a deubiquitinating enzyme, catalyzing ubiquitin removal from target proteins, thereby influencing various cellular processes such as signal transduction, transcriptional regulation, and cell cycle progression. USP40 is broadly expressed and exists in two isoforms due to alternative splicing, making USP40 a significant player in cellular signaling pathways. USP40 has been identified as a novel target for late-onset Parkinson′s disease, highlighting USP40′s potential role in neurodegenerative disorders. Using anti-USP40 antibody (G-8) in research can provide valuable insights into ubiquitin-mediated regulation and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
USP40 Antibody (G-8) References:
- Deubiquitinating enzymes: their diversity and emerging roles. | Chung, CH. and Baek, SH. 1999. Biochem Biophys Res Commun. 266: 633-40. PMID: 10603300
- A genomic perspective on human proteases. | Southan, C. 2001. FEBS Lett. 498: 214-8. PMID: 11412860
- Human and mouse proteases: a comparative genomic approach. | Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. | Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
- Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. | Li, Y., et al. 2006. Hum Mutat. 27: 1017-23. PMID: 16917932
- Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. | Deng, S., et al. 2007. Breast Cancer Res Treat. 104: 21-30. PMID: 17004105
- Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. | Stegmeier, F., et al. 2007. Nature. 446: 876-81. PMID: 17443180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USP40 Antibody (G-8) | sc-514248 | 200 µg/ml | $316.00 | |||
USP40 Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-527875 | 200 µg Ab; 10 µg BP | $354.00 | |||
USP40 Antibody (G-8): m-IgG1 BP-HRP Bundle | sc-533248 | 200 µg Ab; 20 µg BP | $354.00 | |||
USP40 Antibody (G-8) AC | sc-514248 AC | 500 µg/ml, 25% agarose | $416.00 | |||
USP40 Antibody (G-8) HRP | sc-514248 HRP | 200 µg/ml | $316.00 | |||
USP40 Antibody (G-8) FITC | sc-514248 FITC | 200 µg/ml | $330.00 | |||
USP40 Antibody (G-8) PE | sc-514248 PE | 200 µg/ml | $343.00 | |||
USP40 Antibody (G-8) Alexa Fluor® 488 | sc-514248 AF488 | 200 µg/ml | $357.00 | |||
USP40 Antibody (G-8) Alexa Fluor® 546 | sc-514248 AF546 | 200 µg/ml | $357.00 | |||
USP40 Antibody (G-8) Alexa Fluor® 594 | sc-514248 AF594 | 200 µg/ml | $357.00 | |||
USP40 Antibody (G-8) Alexa Fluor® 647 | sc-514248 AF647 | 200 µg/ml | $357.00 | |||
USP40 Antibody (G-8) Alexa Fluor® 680 | sc-514248 AF680 | 200 µg/ml | $357.00 | |||
USP40 Antibody (G-8) Alexa Fluor® 790 | sc-514248 AF790 | 200 µg/ml | $357.00 |