USP34 Antibody (3H9): sc-100631

USP34 Antibody (3H9) is a mouse monoclonal IgG2a kappa light chain antibody that detects USP34 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-USP34 antibody (3H9) is available as a non-conjugated format. USP34 protein consists of 3,395 amino acids and plays a crucial role in the ubiquitin-proteasome system, functioning as a deubiquitinating enzyme that removes ubiquitin moieties from target proteins. This activity is vital for regulating protein stability and function, particularly in response to cellular stressors such as DNA damage, where USP34 is phosphorylated by ATM or ATR kinases. By cleaving ubiquitin from both ubiquitinylated proteins and ubiquitin-fused precursors, USP34 prevents degradation by the proteasome, thereby maintaining essential cellular functions. USP34 is expressed at low levels in the brain and has two isoforms resulting from alternative splicing, which may contribute to diverse regulatory roles in various cellular processes. USP34′s ability to modulate the ubiquitin pathway underscores its importance in signal transduction, transcriptional regulation, and cell cycle control, making USP34 a significant target for research in cancer and other diseases where these processes are disrupted.

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USP34 Antibody (3H9) References:

1. Human and mouse proteases: a comparative genomic approach.  |  Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.  |  Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
3. Phosphoproteomic analysis of the developing mouse brain.  |  Ballif, BA., et al. 2004. Mol Cell Proteomics. 3: 1093-101. PMID: 15345747
4. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.  |  Mu, JJ., et al. 2007. J Biol Chem. 282: 17330-4. PMID: 17478428
5. A newly recognised microdeletion syndrome involving 2p15p16.1: narrowing down the critical region by adding another patient detected by genome wide tiling path array comparative genomic hybridisation analysis.  |  de Leeuw, N., et al. 2008. J Med Genet. 45: 122-4. PMID: 18245392

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USP34 Antibody (3H9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-USP34 Antibody (3H9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USP34 Antibody (3H9) Specifications

Alternate Product Name: USP34

Product Clone Name: 3H9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 3296-3396

Epitope Target: USP34

Epitope Species: human

Product Reactivity/Detection: USP34

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for USP34 Antibody (3H9): N/A