USP3 Antibody (8L8): sc-135597

USP3 Antibody (8L8) is a mouse monoclonal IgG2a kappa light chain antibody that detects USP3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-USP3 antibody (8L8) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. USP3, or ubiquitin specific peptidase 3, is a 520 amino acid protein that plays a vital role in the ubiquitin-proteasome system, which is essential for regulating various cellular processes, including protein degradation, signal transduction, and cell cycle progression. One of the key features of USP3 is its ability to catalyze the hydrolysis of ubiquitin from ubiquitin-conjugated substrates, thereby reversing the action of ubiquitination. This function is crucial because USP3 helps maintain protein homeostasis within the cell and can influence the stability and activity of numerous signaling proteins. The gene encoding USP3 is located on human chromosome 15, a region that contains over 700 genes and is implicated in various genetic disorders. With widespread expression, particularly in the pancreas, USP3 is integral to cellular responses to stress and has been linked to several diseases, making USP3 an important target for therapeutic research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

USP3 Antibody (8L8) References:

1. Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease.  |  Sloper-Mould, KE., et al. 1999. J Biol Chem. 274: 26878-84. PMID: 10480896
2. Deubiquitinating enzymes: their diversity and emerging roles.  |  Chung, CH. and Baek, SH. 1999. Biochem Biophys Res Commun. 266: 633-40. PMID: 10603300
3. Human and mouse proteases: a comparative genomic approach.  |  Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
4. Identification of a short form of ubiquitin-specific protease 3 that is a repressor of rat glutathione S-transferase gene expression.  |  Whalen, R., et al. 2006. Biochem J. 394: 519-26. PMID: 16279867
5. Human USP3 is a chromatin modifier required for S phase progression and genome stability.  |  Nicassio, F., et al. 2007. Curr Biol. 17: 1972-7. PMID: 17980597

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USP3 Antibody (8L8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-USP3 Antibody (8L8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USP3 Antibody (8L8) Specifications

Alternate Product Name: USP3

Product Clone Name: 8L8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 421-521

Epitope Target: USP3

Epitope Species: human

Product Reactivity/Detection: USP3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for USP3 Antibody (8L8): N/A