USH1G Antibody (D-10): sc-514418

USH1G Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects USH1G protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). USH1G (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. USH1G protein, also known as ANKS4A or SANS, is a 461 amino acid protein characterized by three ankyrin repeats and one sterile alpha motif (SAM) domain, which are crucial for structural integrity and function. USH1G protein is predominantly expressed in the small intestine, as well as in the eye and inner ear tissues, where USH1G protein plays a vital role in the development and maintenance of auditory and visual systems by facilitating the cohesion of hair bundles formed by inner ear sensory cells. USH1G protein interaction with Harmonin is particularly significant, as this interaction is believed to be essential for proper functioning of the auditory system. Mutations in the gene encoding USH1G lead to Usher syndrome type 1G, a condition marked by profound congenital sensorineural deafness, absent vestibular function, and early onset of progressive retinitis pigmentosa, ultimately resulting in blindness.

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USH1G Antibody (D-10) References:

1. Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice.  |  Kikkawa, Y., et al. 2003. Hum Mol Genet. 12: 453-61. PMID: 12588793
2. Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin.  |  Weil, D., et al. 2003. Hum Mol Genet. 12: 463-71. PMID: 12588794
3. Ultrastructural findings in the inner ear of Jackson shaker mice.  |  Kitamura, K., et al. 1992. Acta Otolaryngol. 112: 622-7. PMID: 1442008
4. Interactions in the network of Usher syndrome type 1 proteins.  |  Adato, A., et al. 2005. Hum Mol Genet. 14: 347-56. PMID: 15590703
5. Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population.  |  Ouyang, XM., et al. 2005. Hum Genet. 116: 292-9. PMID: 15660226
6. Screening of the USH1G gene among Spanish patients with Usher syndrome. Lack of mutations and evidence of a minor role in the pathogenesis of the syndrome.  |  Aller, E., et al. 2007. Ophthalmic Genet. 28: 151-5. PMID: 17896313
7. UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.  |  Baux, D., et al. 2008. Hum Mutat. 29: E76-87. PMID: 18484607
8. Novel USH1G homozygous variant underlying USH2-like phenotype of Usher syndrome.  |  D'Esposito, F., et al. 2021. Eur J Ophthalmol. 31: NP18-NP22. PMID: 31566003
9. SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes.  |  Yildirim, A., et al. 2021. Nucleic Acids Res. 49: 5845-5866. PMID: 34023904
10. Pathogenic Variants in USH1G/SANS Alter Protein Interaction with Pre-RNA Processing Factors PRPF6 and PRPF31 of the Spliceosome.  |  Fritze, JS., et al. 2023. Int J Mol Sci. 24: PMID: 38139438

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USH1G Antibody (D-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-USH1G Antibody (D-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USH1G Antibody (D-10) Specifications

Alternate Product Name: USH1G

Product Clone Name: D-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-17

Epitope Target: USH1G

Epitope Species: human

Product Reactivity/Detection: USH1G

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for USH1G Antibody (D-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin