USF-1 Antibody (J-39): sc-101197
- USF-1 Antibody (J-39) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant USF-1 of human origin
- recommended for detection of USF-1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for USF-1 Antibody (J-39). This work is in progress.
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USF-1 Antibody (J-39) is a mouse monoclonal IgG1 antibody that detects USF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). USF-1, a member of the cellular upstream stimulatory factor family, plays a crucial role in transcriptional regulation by binding to specific DNA sequences, particularly the core sequence CACGTG found in the adenovirus late promoter. Anti-USF-1 antibody (J-39) enables research into binding mechanisms essential for regulating genes involved in cell growth and differentiation. USF-1′s ability to form homo- and heterodimers with USF-2 allows for a versatile regulatory mechanism that adapts to specific needs of different cell types, as expression levels and ratios of these dimers vary across tissues. USF-1 contains a helix-loop-helix domain facilitating DNA interaction, as well as a leucine repeat enhancing binding efficiency. Understanding USF-1 dynamics and interactions is vital for elucidating complex regulatory networks governing gene expression in response to various stimuli, making USF-1 (J-39) monoclonal antibody an invaluable tool for studying transcriptional regulation and its implications in health and disease.
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USF-1 Antibody (J-39) References:
- Epithelial monolayer wounding stimulates binding of USF-1 to an E-box motif in the plasminogen activator inhibitor type 1 gene. | Providence, KM., et al. 2002. J Cell Sci. 115: 3767-77. PMID: 12235287
- Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. | Corre, S., et al. 2009. J Biol Chem. 284: 18851-62. PMID: 19389701
- USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. | Baron, Y., et al. 2012. PLoS Genet. 8: e1002470. PMID: 22291606
- USF-1 inhibition protects against oxygen-and-glucose-deprivation-induced apoptosis via the downregulation of miR-132 in HepG2 cells. | Wang, R., et al. 2014. Biochem Biophys Res Commun. 446: 1053-9. PMID: 24661879
- Upstream Stimulating Factor 1 (USF-1) Gene Polymorphisms and the Risk, Symptoms, and Outcome of Pediatric Ischemic Stroke. | Balcerzyk, A., et al. 2018. J Stroke Cerebrovasc Dis. 27: 1885-1889. PMID: 29598907
- Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1). | Noguchi, K., et al. 2018. J Biol Chem. 293: 11401-11414. PMID: 29871931
- Phosphorylation of E-box binding USF-1 by PI3K/AKT enhances its transcriptional activation of the WBP2 oncogene in breast cancer cells. | Ramos, A., et al. 2018. FASEB J. fj201801167RR. PMID: 30183375
- Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis. | Baidya, A., et al. 2022. J Biomed Sci. 29: 97. PMID: 36376872
- The metabolic regulator USF-1 is involved in the control of affective behaviour in mice. | Sideromenos, S., et al. 2022. Transl Psychiatry. 12: 497. PMID: 36450713
- Cooperative interaction of ets-1 with USF-1 required for HIV-1 enhancer activity in T cells. | Sieweke, MH., et al. 1998. EMBO J. 17: 1728-39. PMID: 9501094
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
USF-1 Antibody (J-39) | sc-101197 | 100 µg/ml | $339.00 |