UROD Antibody (C-4): sc-365297
- UROD Antibody (C-4) is a mouse monoclonal IgG1 κ UROD antibody, cited in 3 publications, provided at 200 µg/ml
- raised against a peptide mapping near the N-terminus of UROD of human origin
- UROD Antibody (C-4) is recommended for detection of UROD of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-UROD Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for UROD Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with UROD Antibody (C-4) (see ordering information below).
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UROD Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects UROD protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). UROD (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Uroporphyrinogen decarboxylase (UROD) is a crucial 367 amino acid protein that functions as a homodimer and plays a vital role in the heme biosynthetic pathway. Specifically, UROD catalyzes the conversion of uroporphyrinogen to coproporphyrinogen by removing four carboxymethyl side chains, a process essential for proper synthesis of heme, which is critical for oxygen transport and various enzymatic reactions in the body. Disruptions in UROD function due to genetic mutations can lead to significant health issues, including familial porphyria cutanea tarda, sporadic porphyria cutanea tarda, and hepatoerythropoietic porphyria, each associated with varying degrees of skin sensitivity, liver damage, and metabolic disturbances. Anti-UROD antibody (C-4) facilitates research into these disorders and the broader implications of heme metabolism in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UROD Antibody (C-4) References:
- Screening for mutations in the uroporphyrinogen decarboxylase gene using denaturing gradient gel electrophoresis. Identification and characterization of six novel mutations associated with familial PCT. | Christiansen, L., et al. 1999. Hum Mutat. 14: 222-32. PMID: 10477430
- Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase. | Phillips, JD., et al. 2001. Blood. 98: 3179-85. PMID: 11719352
- Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP). | Phillips, JD., et al. 2007. Transl Res. 149: 85-91. PMID: 17240319
- Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase. | Wang, Y., et al. 2008. Anal Chem. 80: 2599-605. PMID: 18294003
- Novel human pathological mutations. Gene symbol: UROD. Disease: porphyria, cutaneous. | Brancaleoni, V., et al. 2007. Hum Genet. 122: 415. PMID: 18350650
- Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria. | Moran-Jimenez, MJ., et al. 1996. Am J Hum Genet. 58: 712-21. PMID: 8644733
- Characterization and crystallization of human uroporphyrinogen decarboxylase. | Phillips, JD., et al. 1997. Protein Sci. 6: 1343-6. PMID: 9194196
- Chromosomal linkage analysis of porphyria in mice induced by hexachlorobenzene-iron synergism: a model of sporadic porphyria cutanea tarda. | Akhtar, RA. and Smith, AG. 1998. Pharmacogenetics. 8: 485-94. PMID: 9918132
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UROD Antibody (C-4) | sc-365297 | 200 µg/ml | $322.00 | |||
UROD Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-529345 | 200 µg Ab; 10 µg BP | $361.00 | |||
UROD Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-522195 | 200 µg Ab, 40 µg BP | $361.00 | |||
UROD Antibody (C-4): m-IgG1 BP-HRP Bundle | sc-543469 | 200 µg Ab; 20 µg BP | $361.00 | |||
UROD Antibody (C-4) AC | sc-365297 AC | 500 µg/ml, 25% agarose | $424.00 | |||
UROD Antibody (C-4) HRP | sc-365297 HRP | 200 µg/ml | $322.00 | |||
UROD Antibody (C-4) FITC | sc-365297 FITC | 200 µg/ml | $336.00 | |||
UROD Antibody (C-4) PE | sc-365297 PE | 200 µg/ml | $349.00 | |||
UROD Antibody (C-4) Alexa Fluor® 488 | sc-365297 AF488 | 200 µg/ml | $364.00 | |||
UROD Antibody (C-4) Alexa Fluor® 546 | sc-365297 AF546 | 200 µg/ml | $364.00 | |||
UROD Antibody (C-4) Alexa Fluor® 594 | sc-365297 AF594 | 200 µg/ml | $364.00 | |||
UROD Antibody (C-4) Alexa Fluor® 647 | sc-365297 AF647 | 200 µg/ml | $364.00 | |||
UROD Antibody (C-4) Alexa Fluor® 680 | sc-365297 AF680 | 200 µg/ml | $364.00 | |||
UROD Antibody (C-4) Alexa Fluor® 790 | sc-365297 AF790 | 200 µg/ml | $364.00 | |||
UROD (C-4) Neutralizing Peptide | sc-365297 P | 100 µg/0.5 ml | $69.00 |