Urm1 Antibody (A-7): sc-374485

Urm1 Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Urm1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Urm1 antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Urm1 protein, or ubiquitin-related modifier 1 homolog, is a 101 amino acid protein that plays a crucial role in the post-translational modification of proteins through the urmylation pathway. This process regulates various cellular functions, including the oxidative-stress response, by modifying target proteins and influencing their stability and activity. In Saccharomyces cerevisiae studies, Urm1 has been shown to covalently bind to E1 activating enzyme, Uba4p, facilitating the conjugation of alkyl hydroperoxide reductase (Ahp1). This interaction suggests Urm1 may be involved in cellular responses to oxidative stress, highlighting its importance in maintaining cellular homeostasis and protecting against damage from reactive oxygen species.

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Urm1 Antibody (A-7) References:

1. Evolution and function of ubiquitin-like protein-conjugation systems.  |  Hochstrasser, M. 2000. Nat Cell Biol. 2: E153-7. PMID: 10934491
2. Biochemistry. All in the ubiquitin family.  |  Hochstrasser, M. 2000. Science. 289: 563-4. PMID: 10939967
3. Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast.  |  Goehring, AS., et al. 2003. Mol Biol Cell. 14: 4329-41. PMID: 14551258
4. Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p.  |  Goehring, AS., et al. 2003. Eukaryot Cell. 2: 930-6. PMID: 14555475
5. Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1.  |  Singh, S., et al. 2005. Protein Sci. 14: 2095-102. PMID: 16046629
6. Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization.  |  Yang, XY., et al. 2005. Cell Oncol. 27: 215-23. PMID: 16308470
7. Solution structure of Urm1 and its implications for the origin of protein modifiers.  |  Xu, J., et al. 2006. Proc Natl Acad Sci U S A. 103: 11625-30. PMID: 16864801
8. Crystal structure of the dimeric Urm1 from the yeast Saccharomyces cerevisiae.  |  Yu, J. and Zhou, CZ. 2008. Proteins. 71: 1050-5. PMID: 18260097

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Urm1 Antibody (A-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Urm1 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Urm1 Antibody (A-7) Specifications

Alternate Product Name: Urm1

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Urm1

Epitope Species: human

Product Reactivity/Detection: Urm1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Urm1 Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin