Urm1 Inhibitors
Urm1 inhibitors belong to a specialized chemical class designed to modulate the function of Urm1, an evolutionarily conserved protein that plays a crucial role in post-translational modification processes. Urm1, also known as Ubiquitin-related modifier 1, is a member of the ubiquitin-like protein family and is involved in various cellular functions, particularly the regulation of protein homeostasis. Inhibitors targeting Urm1 aim to manipulate its activity, leading to downstream effects on cellular pathways.
The Urm1 inhibitors typically act by disrupting the enzymatic activity of Urm1 ligases, key components responsible for conjugating Urm1 to target proteins. These inhibitors are meticulously designed to interact with the active site of Urm1 ligases, thereby preventing the covalent attachment of Urm1 to its substrates. By interfering with this conjugation process, Urm1 inhibitors influence the cellular response to stress, protein quality control mechanisms, and other vital pathways associated with Urm1 function. The development and exploration of Urm1 inhibitors represent a targeted approach in understanding the intricate network of ubiquitin-like modifiers and their impact on cellular physiology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin can inhibit thioredoxin reductase, thereby influencing the cellular redox state and indirectly affecting Urm1-related oxidative stress pathways. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit various enzymes involved in sulfur metabolism, thus potentially altering Urm1-related pathways. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide reacts with sulfhydryl groups on cysteines, potentially disrupting proteins that interact with Urm1. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $280.00 $433.00 $1502.00 $2917.00 | 26 | |
This compound inhibits gamma-glutamylcysteine synthetase, which can affect glutathione synthesis, a key molecule in oxidative stress where Urm1 functions might be implicated. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium Arsenite can disrupt thiol-containing enzymes and proteins, potentially affecting Urm1 pathways. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium Chloride can interfere with sulfur-containing proteins and peptides, indirectly affecting Urm1-related processes. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic Trioxide can bind to vicinal thiols, which may affect enzymes and proteins interacting with Urm1. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can alkalize cellular compartments and affect protein modification pathways, potentially influencing Urm1's role in these pathways. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
This compound can modify cysteine residues in proteins, potentially affecting Urm1 interactions. | ||||||