uPAR Antibody (E-3): sc-376494

uPAR Antibody (E-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects uPAR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). uPAR (E-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The urokinase plasminogen activator receptor (uPAR), also known as CD87, is a glycoprotein anchored to the cell surface and plays a critical role in regulating pericellular proteolysis. uPAR specifically binds to urokinase plasminogen activator (uPA), which catalyzes plasminogen conversion to plasmin, a serine protease essential for fibrin degradation in the extracellular matrix. This process is vital for various physiological functions, including tissue remodeling, wound healing, and inflammatory response. The interaction between uPA and uPAR is implicated in tumor biology, as both proteins are often overexpressed in cancer cells, facilitating tumor invasion and metastasis. The signaling cascade initiated by uPA binding to uPAR involves key downstream effectors such as Ras, MEK, ERK, and MLCK, which collectively promote cellular migration in a manner selective for integrins. This makes uPAR a significant target for therapeutic interventions aimed at inhibiting cancer progression and metastasis.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-uPAR Antibody (E-3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-uPAR Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

uPAR Antibody (E-3) Specifications

Alternate Product Name: CD87

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-290

Epitope Target: uPAR

Epitope Species: human

Product Reactivity/Detection: uPAR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for uPAR Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred uPAR antibody is uPAR Antibody (10G7): sc-13522.