uPAR Antibody (D-5): sc-376118

uPAR Antibody (D-5) is a mouse monoclonal IgG1 antibody that detects urokinase plasminogen activator receptor (uPAR) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). uPAR, also known as CD87, is a glycoprotein I-anchored surface receptor that plays a crucial role in the regulation of pericellular proteolysis by binding to urokinase plasminogen activator (uPA). This interaction facilitates the conversion of plasminogen to plasmin, a serine protease essential for degrading fibrin and fibrinogen, thereby influencing the coagulation cascade. uPAR′s significance extends beyond normal physiological processes like wound healing and tissue remodeling to pathological conditions, particularly cancer. uPAR and uPA are often overexpressed in tumor cells of mesenchymal and epithelial origin, contributing to tumor invasion and metastasis. The signaling cascade initiated by uPA binding to uPAR involves key downstream effectors such as Ras, MEK, ERK, and MLCK, which collectively promote cellular migration in a manner selective for integrins. anti-uPAR antibody (D-5) serves as an invaluable tool for researchers studying cancer progression mechanisms and proteolytic enzymes in tissue dynamics.

The preferred uPAR antibody is uPAR Antibody (10G7): sc-13522.