UNC5H3 Antibody (Zg06): sc-80422
- UNC5H3 Antibody (Zg06) is a mouse monoclonal IgG2b, cited in 1 publications, provided at 100 µg/ml
- raised against an extracellular domain of UNC5H3 of human origin
- recommended for detection of UNC5H3 of mouse, rat and human origin by WB, IF and IHC(P); non cross-reactive with Unc5H4
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for UNC5H3 Antibody (Zg06). This work is in progress.
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UNC5H3 Antibody (Zg06) is a mouse monoclonal IgG2b antibody that detects UNC5H3 in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. UNC5H3, also known as UNC5C, is a member of the UNC5H family of proteins, which serve as transmembrane receptors for netrin-1, playing a pivotal role in axon guidance and neural cell migration. UNC5H3 mediates the repulsive action of netrin-1 and acts as a critical stop signal for migratory cells, ensuring proper neuronal development and positioning. When cleaved by caspases, UNC5H3 can induce apoptosis through the generation of an intracellular fragment containing a death domain, a process inhibited by netrin-1 binding. In the absence of netrin-1, UNC5H3 functions as a tumor suppressor, inhibiting anchorage-independent growth and invasion, which is particularly significant given that UNC5H3 expression is down-regulated in various cancers, including colorectal, breast, ovarian, uterine, stomach, lung, and kidney cancers. UNC5H3′s influence on both neural development and cancer progression underscores its importance as a target for research and therapeutic interventions.
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UNC5H3 Antibody (Zg06) References:
- Granule cells and cerebellar boundaries: analysis of Unc5h3 mutant chimeras. | Goldowitz, D., et al. 2000. J Neurosci. 20: 4129-37. PMID: 10818148
- The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. | Finger, JH., et al. 2002. J Neurosci. 22: 10346-56. PMID: 12451134
- Insertional mutation in the intron 1 of Unc5h3 gene induces ataxic, lean and hyperactive phenotype in mice. | Choi, YS., et al. 2003. Exp Anim. 52: 273-83. PMID: 14562603
- Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3. | Kuramoto, T., et al. 2004. Brain Res Mol Brain Res. 122: 103-8. PMID: 15010202
- Netrins and UNC5 receptors in angiogenesis. | Freitas, C., et al. 2008. Angiogenesis. 11: 23-9. PMID: 18266062
- UNC5 dependence receptor family in human cancer: A controllable double-edged sword. | Zhu, Y., et al. 2021. Cancer Lett. 516: 28-35. PMID: 34077783
- GPC3-Unc5 receptor complex structure and role in cell migration. | Akkermans, O., et al. 2022. Cell. 185: 3931-3949.e26. PMID: 36240740
- Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling. | Prigge, CL., et al. 2023. Dev Cell. 58: 2080-2096.e7. PMID: 37557174
- The regulatory role of the Netrin-1/UNC5H3 pathway in neuronal pyroptosis after stroke. | Zhai, Z., et al. 2025. Int Immunopharmacol. 146: 113939. PMID: 39740525
- Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. | Przyborski, SA., et al. 1998. Development. 125: 41-50. PMID: 9389662
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UNC5H3 Antibody (Zg06) | sc-80422 | 100 µg/ml | $322.00 |