UHRF1 Antibody (G-3): sc-365392

UHRF1 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects UHRF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UHRF1, also known as Np95, ICBP90, or RNF106, is a crucial transcription and cell cycle regulator that belongs to the RING-finger type E3 ubiquitin ligase subfamily. UHRF1 is primarily localized in the nucleus, where UHRF1 plays a vital role in mediating the ubiquitination process, which is essential for protein degradation and cellular proliferation. UHRF1 contains multiple functional domains, including a PHD-type zinc finger, a ubiquitin-like domain, and two RING-type zinc fingers, which facilitate interaction with various proteins, including Dnmt1, a maintenance DNA methyltransferase. The interaction between UHRF1 and Dnmt1 is particularly significant as this ensures the stable association of Dnmt1 with chromatin, thereby influencing DNA methylation patterns that are critical for gene regulation and cellular identity. Notably, UHRF1 is often overexpressed in cancer cells, highlighting its potential role in carcinogenesis and making UHRF1 a target of interest for cancer research. anti-UHRF1 antibody (G-3) is an invaluable tool for researchers aiming to explore the intricate mechanisms of cell cycle regulation and the implications of UHRF1 in various diseases.

The preferred UHRF1 antibody is UHRF1 Antibody (H-8): sc-373750.