UHRF1 Antibody (G-2): sc-166898
- UHRF1 Antibody (G-2) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 279-343 mapping within an internal region of UHRF1 of human origin
- recommended for detection of UHRF1 of human origin by WB, IP, IF, IHC(P) and ELISA
- See UHRF1 (H-8): sc-373750 for UHRF1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for UHRF1 Antibody (G-2) for WB and IHC(P) applications. These reagents are now offered in bundles with UHRF1 Antibody (G-2) (see ordering information below).
QUICK LINKS
SEE ALSO...
UHRF1 Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects UHRF1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). UHRF1, also known as Np95, ICBP90, or RNF106, is a crucial transcription and cell cycle regulator that belongs to the RING-finger type E3 ubiquitin ligase subfamily. UHRF1 is predominantly localized in the nucleus, where UHRF1 plays a vital role in cellular proliferation by functioning as an E3 ubiquitin-protein ligase. UHRF1 facilitates the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to target proteins, marking them for degradation, which is essential for maintaining cellular homeostasis and regulating the cell cycle. Additionally, UHRF1 directly interacts with Dnmt1, a maintenance DNA methyltransferase, ensuring stable association with chromatin, which is critical for the regulation of gene expression and epigenetic inheritance. Overexpression of UHRF1 in cancer cells highlights potential involvement in carcinogenesis, making UHRF1 a significant target for cancer research. With comprehensive reactivity and functional importance, anti-UHRF1 antibody (G-2) is an invaluable tool for researchers studying the mechanisms of cell cycle regulation and the implications of ubiquitination in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UHRF1 Antibody (G-2) | sc-166898 | 200 µg/ml | $322.00 | |||
UHRF1 Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-540174 | 200 µg Ab; 10 µg BP | $361.00 | |||
UHRF1 Antibody (G-2): m-IgG2a BP-HRP Bundle | sc-546867 | 200 µg Ab; 10 µg BP | $361.00 |