UDP-GlcDH Antibody (B-4): sc-137058
- UDP-GlcDH Antibody (B-4) is a mouse monoclonal IgG2a κ UDP-GlcDH antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 195-494 mapping at the C-terminus of UDP-GlcDH of human origin
- UDP-GlcDH Antibody (B-4) is recommended for detection of UDP-glucose-6 dehydrogenase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine
- Anti-UDP-GlcDH Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for UDP-GlcDH Antibody (B-4) for WB and IHC(P) applications. These reagents are now offered in bundles with UDP-GlcDH Antibody (B-4) (see ordering information below).
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UDP-GlcDH Antibody (B-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects UDP-GlcDH of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). UDP-GlcDH (B-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UDP-GlcDH, also known as UDP-glucose 6-dehydrogenase, UGDH, or UDPGDH, plays a vital role in converting UDP-glucose to UDP-glucuronic acid, a key precursor in glycosaminoglycan biosynthesis such as hyaluronan, heparan sulfate, and chondroitin sulfate. These glycosaminoglycans are essential components of the extracellular matrix, contributing significantly to processes such as signal transduction, cell migration, and cancer progression. UDP-glucuronic acid is crucial for liver detoxification and excretion of harmful compounds. UDP-GlcDH shows ubiquitous expression, with highest abundance in liver, and forms a homohexamer structure that is highly conserved across species, showing 97% sequence identity among mammals. Research has shown that UDP-GlcDH expression increases with transforming growth factor beta (TGFβ) and decreases under hypoxic conditions, highlighting a regulatory role in cellular responses to environmental changes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UDP-GlcDH Antibody (B-4) References:
- Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping. | Marcu, O., et al. 1999. Cytogenet Cell Genet. 86: 244-5. PMID: 10575217
- Molecular cloning and characterization of a cDNA encoding poplar UDP-glucose dehydrogenase, a key gene of hemicellulose/pectin formation. | Johansson, H., et al. 2002. Biochim Biophys Acta. 1576: 53-8. PMID: 12031484
- Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. | Bontemps, Y., et al. 2003. J Biol Chem. 278: 21566-75. PMID: 12682078
- Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript. | Vatsyayan, J., et al. 2005. J Biochem. 137: 703-9. PMID: 16002992
- Inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells. | Huh, JW., et al. 2005. Biotechnol Lett. 27: 1229-32. PMID: 16158268
- UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases. | Hempel, J., et al. 1994. Protein Sci. 3: 1074-80. PMID: 7920253
- Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. | Spicer, AP., et al. 1998. J Biol Chem. 273: 25117-24. PMID: 9737970
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UDP-GlcDH Antibody (B-4) | sc-137058 | 200 µg/ml | $322.00 | |||
UDP-GlcDH Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-528850 | 200 µg Ab; 10 µg BP | $361.00 | |||
UDP-GlcDH Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-521409 | 200 µg Ab, 40 µg BP | $361.00 | |||
UDP-GlcDH Antibody (B-4): m-IgG2a BP-HRP Bundle | sc-547189 | 200 µg Ab; 10 µg BP | $361.00 | |||
UDP-GlcDH Antibody (B-4) AC | sc-137058 AC | 500 µg/ml, 25% agarose | $424.00 | |||
UDP-GlcDH Antibody (B-4) HRP | sc-137058 HRP | 200 µg/ml | $322.00 | |||
UDP-GlcDH Antibody (B-4) FITC | sc-137058 FITC | 200 µg/ml | $336.00 | |||
UDP-GlcDH Antibody (B-4) PE | sc-137058 PE | 200 µg/ml | $349.00 | |||
UDP-GlcDH Antibody (B-4) Alexa Fluor® 488 | sc-137058 AF488 | 200 µg/ml | $364.00 | |||
UDP-GlcDH Antibody (B-4) Alexa Fluor® 546 | sc-137058 AF546 | 200 µg/ml | $364.00 | |||
UDP-GlcDH Antibody (B-4) Alexa Fluor® 594 | sc-137058 AF594 | 200 µg/ml | $364.00 | |||
UDP-GlcDH Antibody (B-4) Alexa Fluor® 647 | sc-137058 AF647 | 200 µg/ml | $364.00 | |||
UDP-GlcDH Antibody (B-4) Alexa Fluor® 680 | sc-137058 AF680 | 200 µg/ml | $364.00 | |||
UDP-GlcDH Antibody (B-4) Alexa Fluor® 790 | sc-137058 AF790 | 200 µg/ml | $364.00 |