UCP2 Antibody (G-6): sc-390189

UCP2 Antibody (G-6) is a mouse monoclonal IgM kappa antibody raised against a peptide mapping at the N-terminus of human mitochondrial uncoupling protein 2 (UCP2) and is reactive with mouse, rat, and human species. UCP2, a member of the solute carrier family 25 (SLC25A8), is an integral mitochondrial inner membrane protein that plays a pivotal role in regulating mitochondrial function and energy metabolism. By acting as a proton carrier, UCP2 uncouples oxidative phosphorylation from ATP synthesis, dissipating the electrochemical gradient across the mitochondrial inner membrane. This uncoupling reduces reactive oxygen species (ROS) production and protects cells from oxidative stress, highlighting UCP2′s importance in cellular defense mechanisms. Unlike UCP1, which is primarily found in brown adipose tissue and is specialized for thermogenesis, UCP2 is widely expressed in various tissues, including white adipose tissue, muscle, and immune cells. UCP2 is implicated in critical physiological processes such as energy balance, glucose metabolism, and regulation of body weight. UCP2′s dysregulation has been associated with metabolic disorders, obesity, type 2 diabetes, and immune response modulation, making UCP2 an essential focus in metabolic and mitochondrial research. Anti-UCP2 antibody (G-6) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), offering researchers a reliable tool for studying this key mitochondrial protein. Anti-UCP2 antibody (G-6) is available in a non-conjugated form, enabling use in a variety of experimental settings to explore UCP2′s roles in health and disease.

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UCP2 Antibody (G-6) References:

1. Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2.  |  Jaburek, M., et al. 2004. J Biol Chem. 279: 53097-102. PMID: 15475368
2. Heterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 protein.  |  Ostrowski, J., et al. 2004. J Biol Chem. 279: 54599-609. PMID: 15485813
3. Overexpression of short heterodimer partner recovers impaired glucose-stimulated insulin secretion of pancreatic beta-cells overexpressing UCP2.  |  Suh, YH., et al. 2004. J Endocrinol. 183: 133-44. PMID: 15525581
4. Brown adipose tissue thermogenesis: interdisciplinary studies.  |  Himms-Hagen, J. 1990. FASEB J. 4: 2890-8. PMID: 2199286
5. Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.  |  Cassard, AM., et al. 1990. J Cell Biochem. 43: 255-64. PMID: 2380264
6. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression.  |  Jacobsson, A., et al. 1985. J Biol Chem. 260: 16250-4. PMID: 2999153
7. Thermogenic mechanisms in brown fat.  |  Nicholls, DG. and Locke, RM. 1984. Physiol Rev. 64: 1-64. PMID: 6320232
8. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.  |  Fleury, C., et al. 1997. Nat Genet. 15: 269-72. PMID: 9054939

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UCP2 Antibody (G-6) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-UCP2 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UCP2 Antibody (G-6) Specifications

Alternate Product Name: UCP2

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: UCP2

Epitope Species: human

Product Reactivity/Detection: UCP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 32 citations in various scientific publications

Available Conjugates/Forms for UCP2 Antibody (G-6): P: Blocking Peptide