UCH-L3 Antibody (ZE-17): sc-100340

UCH-L3 Antibody (ZE-17) is a mouse monoclonal IgG2a kappa light chain antibody that detects UCH-L3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-UCH-L3 antibody (ZE-17) is available as a non-conjugated format. UCH-L3, also known as ubiquitin C-terminal hydrolase L3, plays a crucial role in the ubiquitin-proteasome system, which is essential for protein degradation and regulation within cells. UCH-L3 is primarily located in the cytoplasm and nucleus, where UCH-L3 is involved in hydrolyzing ubiquitin from protein substrates, thereby recycling ubiquitin for further use in cellular processes. UCH-L3′s ability to maintain ubiquitin homeostasis is vital for various cellular functions, including cell cycle regulation, DNA repair, and response to oxidative stress. Dysregulation of UCH-L3 has been implicated in several neurodegenerative diseases, making UCH-L3 a significant target for research in understanding molecular mechanisms underlying these conditions. The gene encoding UCH-L3 is located on human chromosome 4p14, and UCH-L3 consists of 230 amino acids, exhibiting a high degree of conservation across species, which underscores UCH-L3′s importance in cellular function.

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UCH-L3 Antibody (ZE-17) References:

1. Intron-exon structure of ubiquitin c-terminal hydrolase-L1.  |  Leroy, E., et al. 1998. DNA Res. 5: 397-400. PMID: 10048490
2. The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14.  |  Edwards, YH., et al. 1991. Ann Hum Genet. 55: 273-8. PMID: 1840236
3. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.  |  Wilkinson, KD., et al. 1989. Science. 246: 670-3. PMID: 2530630
4. Detection, resolution, and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus.  |  Mayer, AN. and Wilkinson, KD. 1989. Biochemistry. 28: 166-72. PMID: 2539853
5. Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis.  |  Doran, JF., et al. 1983. J Neurochem. 40: 1542-7. PMID: 6343558

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-UCH-L3 Antibody (ZE-17) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-UCH-L3 Antibody (ZE-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

UCH-L3 Antibody (ZE-17) Specifications

Alternate Product Name: UCH-L3

Product Clone Name: ZE-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 131-231

Epitope Target: UCH-L3

Epitope Species: human

Product Reactivity/Detection: UCH-L3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for UCH-L3 Antibody (ZE-17): N/A