UBQLN3 Antibody (B-4): sc-393634
- UBQLN3 Antibody (B-4) is a mouse monoclonal IgG2a κ UBQLN3 antibody provided at 200 µg/ml
- raised against amino acids 357-507 mapping within an internal region of UBQLN3 of mouse origin
- UBQLN3 Antibody (B-4) is recommended for detection of UBQLN3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-UBQLN3 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP is the preferred secondary detection reagent for UBQLN3 Antibody (B-4) for WB applications. This reagent is now offered in a bundle with UBQLN3 Antibody (B-4) (see ordering information below).
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UBQLN3 Antibody (B-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects UBQLN3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UBQLN3 Antibody (B-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UBQLN3, also known as Ubiquilin-3, is a 654 amino acid protein characterized by one N-terminal ubiquitin-like domain and one C-terminal ubiquitin-associated domain. UBQLN3 functions to facilitate the degradation of misfolded and damaged proteins, which is crucial for maintaining cellular homeostasis and preventing the accumulation of potentially toxic proteins. UBQLN3 is predominantly expressed in the testis, where UBQLN3 interacts with testis-specific cyclin A1 and/or cyclin A, playing a significant role in regulating the cell cycle during spermatogenesis. This interaction highlights UBQLN3′s importance not only in protein quality control but also in reproductive biology, as proper cell cycle regulation is essential for successful spermatogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UBQLN3 Antibody (B-4) References:
- Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma. | Song, MH., et al. 2012. Oncol Rep. 28: 1792-8. PMID: 22941507
- Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis. | Malcher, A., et al. 2013. Fertil Steril. 100: 1686-94.e1-7. PMID: 24012201
- Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice. | Yuan, S., et al. 2015. Mol Reprod Dev. 82: 266-7. PMID: 25776854
- MicroRNA-targeting in spermatogenesis: Over-expressions of microRNA-23a/b-3p and its affected targeting of the genes ODF2 and UBQLN3 in spermatozoa of patients with oligoasthenozoospermia. | Abu-Halima, M., et al. 2021. Andrology. 9: 1137-1144. PMID: 33784796
- Impact of platelet-rich plasma versus selenium in ameliorating induced toxicity in rat testis: histological, immunohistochemical, and molecular study. | Sayed, WM. and Elzainy, A. 2021. Cell Tissue Res. 385: 223-238. PMID: 33791879
- HYPK coordinates degradation of polyneddylated proteins by autophagy. | Ghosh, DK. and Ranjan, A. 2022. Autophagy. 18: 1763-1784. PMID: 34836490
- Omics and Male Infertility: Highlighting the Application of Transcriptomic Data. | Omolaoye, TS., et al. 2022. Life (Basel). 12: PMID: 35207567
- Chromosome 17 translocation affects sperm morphology: Two case studies and literature review. | Huang, S., et al. 2022. Andrologia. 54: e14620. PMID: 36270636
- UBQLN Family Members Regulate MYC in Lung Adenocarcinoma Cells. | Shah, PP. and Beverly, LJ. 2023. Cancers (Basel). 15: PMID: 37444499
- Identification of hub genes associated with spermatogenesis by bioinformatics analysis. | Liu, S., et al. 2023. Sci Rep. 13: 18435. PMID: 37891374
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UBQLN3 Antibody (B-4) | sc-393634 | 200 µg/ml | $322.00 | |||
UBQLN3 Antibody (B-4): m-IgG2a BP-HRP Bundle | sc-545966 | 200 µg Ab; 10 µg BP | $361.00 | |||
UBQLN3 Antibody (B-4) AC | sc-393634 AC | 500 µg/ml, 25% agarose | $424.00 | |||
UBQLN3 Antibody (B-4) HRP | sc-393634 HRP | 200 µg/ml | $322.00 | |||
UBQLN3 Antibody (B-4) FITC | sc-393634 FITC | 200 µg/ml | $336.00 | |||
UBQLN3 Antibody (B-4) PE | sc-393634 PE | 200 µg/ml | $349.00 | |||
UBQLN3 Antibody (B-4) Alexa Fluor® 488 | sc-393634 AF488 | 200 µg/ml | $364.00 | |||
UBQLN3 Antibody (B-4) Alexa Fluor® 546 | sc-393634 AF546 | 200 µg/ml | $364.00 | |||
UBQLN3 Antibody (B-4) Alexa Fluor® 594 | sc-393634 AF594 | 200 µg/ml | $364.00 | |||
UBQLN3 Antibody (B-4) Alexa Fluor® 647 | sc-393634 AF647 | 200 µg/ml | $364.00 | |||
UBQLN3 Antibody (B-4) Alexa Fluor® 680 | sc-393634 AF680 | 200 µg/ml | $364.00 | |||
UBQLN3 Antibody (B-4) Alexa Fluor® 790 | sc-393634 AF790 | 200 µg/ml | $364.00 |