UBPY Antibody (A-11): sc-376129
- UBPY Antibody (A-11) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminal of UBPY of human origin
- recommended for detection of UBPY of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for UBPY Antibody (A-11) for WB applications. These reagents are now offered in bundles with UBPY Antibody (A-11) (see ordering information below).
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SEE ALSO...
UBPY Antibody (A-11) is a mouse monoclonal IgG2a antibody that detects UBPY in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UBPY, also known as USP8 (ubiquitin carboxyl-terminal hydrolase 8) or KIAA0055, is a crucial 1,118 amino acid protein that plays a significant role in the ubiquitin pathway, which is essential for regulating various intracellular processes, including signal transduction, transcriptional activation, and cell cycle progression. UBPY contains one rhodanese domain and forms a ternary complex with OTUB1 and GRAIL, highlighting UBPY′s importance in cellular signaling. UBPY functions as a hydrolase, catalyzing the removal of ubiquitin from ubiquitin-conjugated proteins, thereby influencing protein turnover and cellular proliferation. This activity is particularly vital in T-cell anergy, where UBPY helps modulate immune responses. The gene encoding UBPY is located on human chromosome 15, a region that encompasses over 700 genes and constitutes nearly 3% of the human genome, underscoring UBPY′s relevance in a wide array of biological functions. Anti-UBPY antibody (A-11) is an invaluable tool for researchers studying the dynamics of protein ubiquitination and its implications in various cellular processes.
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UBPY Antibody (A-11) References:
- The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells. | Ceriani, M., et al. 2015. Exp Cell Res. 333: 49-59. PMID: 25662281
- USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET. | Berruti, G. and Paiardi, C. 2015. Reproduction. 149: 633-44. PMID: 25744385
- USP8 mutation in Cushing's disease. | Huang, C., et al. 2015. Oncotarget. 6: 18240-1. PMID: 26285834
- The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics. | Islam, MT., et al. 2021. Arch Biochem Biophys. 701: 108811. PMID: 33600786
- Suppression of USP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy. | Liu, L., et al. 2023. Protein Cell. 14: 230-234. PMID: 37051673
- USP8 mitigates cognitive dysfunction of mice with sepsis-associated encephalopathy. | Zhang, L. and Liu, J. 2023. Psychogeriatrics. 23: 713-724. PMID: 37293711
- USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2. | Cui, J., et al. 2023. Biomed Pharmacother. 166: 115359. PMID: 37639742
- Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease. | Rebollar-Vega, RG., et al. 2023. Arch Med Res. 54: 102899. PMID: 37925320
- SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8. | Guo, J., et al. 2024. Cell Mol Immunol. 21: 892-904. PMID: 38906982
- USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT. | Long, G., et al. 2024. Cancer Cell Int. 24: 238. PMID: 38973004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UBPY Antibody (A-11) | sc-376129 | 200 µg/ml | $322.00 | |||
UBPY Antibody (A-11): m-IgG Fc BP-HRP Bundle | sc-540519 | 200 µg Ab; 10 µg BP | $361.00 | |||
UBPY Antibody (A-11): m-IgG2a BP-HRP Bundle | sc-546919 | 200 µg Ab; 10 µg BP | $361.00 |