UBE2L3 Antibody (E-2): sc-390234

UBE2L3 Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects UBE2L3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UBE2L3, also known as UBCH7, is a crucial E2 ubiquitin-conjugating enzyme that plays a significant role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. UBE2L3 is primarily located in the cytoplasm and nucleus, where UBE2L3 facilitates the transfer of ubiquitin to target proteins, thereby influencing various cellular processes, including cell cycle regulation, signal transduction, and responses to stress. Proper functioning of UBE2L3 is vital, as dysregulation of ubiquitination can lead to the accumulation of misfolded proteins and has been implicated in several diseases, including cancer and neurodegenerative disorders. UBE2L3 interacts with a variety of proteins, including the tumor suppressor protein TSSC5 and is involved in the degradation of key regulatory proteins such as c-fos and p53, highlighting UBE2L3′s importance in cellular signaling pathways and tumorigenesis. With insights into the ubiquitin pathway and implications in disease, anti-UBE2L3 antibody (E-2) serves as an invaluable tool for researchers studying protein interactions and post-translational modifications.

The preferred UBE2L3 antibody is UBE2L3 Antibody (B-11): sc-390032.