Tyro3 Antibody (1C11E8): sc-81160
- Tyro3 Antibody (1C11E8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 152-310 of Tyro3 of human origin
- recommended for detection of Tyro3 of human origin by WB, IP and IF
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Tyro3 Antibody (1C11E8) for WB applications. This reagent is now offered in a bundle with Tyro3 Antibody (1C11E8) (see ordering information below).
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SEE ALSO...
Tyro3 Antibody (1C11E8) is a mouse monoclonal IgG1 antibody that detects Tyro3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Tyro3, a member of the Axl/UFO subfamily of receptor tyrosine kinases, plays a crucial role in various biological processes, including spermatogenesis, immunoregulation, and phagocytosis, making Tyro3 essential for maintaining cellular homeostasis and immune responses. Tyro3 is primarily located in the cell membrane, where Tyro3 functions as a transmembrane signaling molecule. The extracellular domain, which consists of two immunoglobulin-like domains and two fibronectin type III domains, facilitates ligand binding and receptor dimerization, leading to the activation of intrinsic tyrosine kinase activity. This activation is vital for downstream signaling pathways that regulate cell growth, survival, and differentiation. Tyro3 is widely expressed in adult tissues, particularly in the brain, testis, lymphatic, and vascular tissues, highlighting Tyro3′s importance in both the central nervous system and the immune system. Additionally, Tyro3 undergoes significant post-translational modifications, including tyrosine phosphorylation and glycosylation, which are critical for functional regulation and interaction with ligands such as Protein S and Gas6. These ligands are known to play roles in coagulation and immune responses, further underscoring Tyro3′s importance in maintaining physiological balance.
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Tyro3 Antibody (1C11E8) References:
- The Emerging Role of TYRO3 as a Therapeutic Target in Cancer. | Smart, SK., et al. 2018. Cancers (Basel). 10: PMID: 30501104
- Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment. | Myers, KV., et al. 2019. Mol Cancer. 18: 94. PMID: 31088471
- TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. | Jiang, Z., et al. 2021. J Clin Invest. 131: PMID: 33855973
- TYRO3 Knockdown Suppresses the Growth of Myeloid Leukaemia Cells. | Saito, T., et al. 2022. Anticancer Res. 42: 1757-1761. PMID: 35346994
- TYRO3 agonist as therapy for glomerular disease. | Zhong, F., et al. 2023. JCI Insight. 8: PMID: 36454644
- Regulation of bone homeostasis by MERTK and TYRO3. | Engelmann, J., et al. 2022. Nat Commun. 13: 7689. PMID: 36509738
- TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment. | Park, M., et al. 2023. J Immunother Cancer. 11: PMID: 36693679
- TYRO3 protects podocyte via JNK/c-jun-P53 pathway. | Zhang, L., et al. 2023. Arch Biochem Biophys. 739: 109578. PMID: 36948351
- Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. | Hsu, PL., et al. 2023. Sci Adv. 9: eade3422. PMID: 37043564
- Role and Mechanisms of Tyro3 in Podocyte Biology and Glomerular Disease. | Min, L., et al. 2024. Kidney Dis (Basel). 10: 398-406. PMID: 39430290
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyro3 Antibody (1C11E8) | sc-81160 | 200 µg/ml | $322.00 | |||
Tyro3 Antibody (1C11E8): m-IgG Fc BP-HRP Bundle | sc-551975 | 200 µg Ab; 10 µg BP | $361.00 |