TUSC5 Antibody (B-4): sc-377025
- TUSC5 Antibody (B-4) is a mouse monoclonal IgG1 κ TUSC5 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-110 mapping at the N-terminus of TUSC5 of mouse origin
- TUSC5 Antibody (B-4) is recommended for detection of TUSC5 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TUSC5 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TUSC5 Antibody (B-4) for WB applications. These reagents are now offered in bundles with TUSC5 Antibody (B-4) (see ordering information below).
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TUSC5 Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects TUSC5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TUSC5 (B-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TUSC5, also known as tumor suppressor candidate 5, is a 177 amino acid multi-pass membrane protein that plays a crucial role in fat metabolism and is highly expressed in tissues such as mammary gland, heart, smooth muscle, skeletal muscle, and stomach, with lower expression levels in lung and brain. TUSC5′s location within the cell membrane suggests a role in cellular signaling and interaction with other membrane proteins, which can influence metabolic pathways and cellular responses to external stimuli. TUSC5 is located on human chromosome 17, a region critical for tumor suppression, housing important genes like p53 and BRCA1, both involved in DNA repair mechanisms and cancer predisposition. Loss or malfunction of TUSC5 may contribute to dysregulation of these pathways, highlighting potential importance in cancer biology and metabolic disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TUSC5 Antibody (B-4) References:
- p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis. | Soussi, T., et al. 2000. Hum Mutat. 15: 105-13. PMID: 10612830
- Distinct pattern of p53 phosphorylation in human tumors. | Minamoto, T., et al. 2001. Oncogene. 20: 3341-7. PMID: 11423984
- Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier. | Piura, B., et al. 2001. Eur J Obstet Gynecol Reprod Biol. 97: 241-4. PMID: 11451557
- Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer. | Konishi, H., et al. 2003. Oncogene. 22: 1892-905. PMID: 12660825
- Closing in on a breast cancer gene on chromosome 17q. | Hall, JM., et al. 1992. Am J Hum Genet. 50: 1235-42. PMID: 1598904
- Tumor suppressor candidate 5 (TUSC5) is expressed in brown adipocytes. | Koide, H., et al. 2007. Biochem Biophys Res Commun. 360: 139-45. PMID: 17592729
- Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons. | Oort, PJ., et al. 2007. Mol Cell Endocrinol. 276: 24-35. PMID: 17689857
- The Li-Fraumeni syndrome: an inherited susceptibility to cancer. | Evans, SC. and Lozano, G. 1997. Mol Med Today. 3: 390-5. PMID: 9302689
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TUSC5 Antibody (B-4) | sc-377025 | 200 µg/ml | $316.00 | |||
TUSC5 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-529958 | 200 µg Ab; 10 µg BP | $354.00 | |||
TUSC5 Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-523155 | 200 µg Ab, 40 µg BP | $354.00 | |||
TUSC5 Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-543788 | 200 µg Ab; 20 µg BP | $354.00 | |||
TUSC5 Antibody (B-4) AC | sc-377025 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TUSC5 Antibody (B-4) HRP | sc-377025 HRP | 200 µg/ml | $316.00 | |||
TUSC5 Antibody (B-4) FITC | sc-377025 FITC | 200 µg/ml | $330.00 | |||
TUSC5 Antibody (B-4) PE | sc-377025 PE | 200 µg/ml | $343.00 | |||
TUSC5 Antibody (B-4) Alexa Fluor® 488 | sc-377025 AF488 | 200 µg/ml | $357.00 | |||
TUSC5 Antibody (B-4) Alexa Fluor® 546 | sc-377025 AF546 | 200 µg/ml | $357.00 | |||
TUSC5 Antibody (B-4) Alexa Fluor® 594 | sc-377025 AF594 | 200 µg/ml | $357.00 | |||
TUSC5 Antibody (B-4) Alexa Fluor® 647 | sc-377025 AF647 | 200 µg/ml | $357.00 | |||
TUSC5 Antibody (B-4) Alexa Fluor® 680 | sc-377025 AF680 | 200 µg/ml | $357.00 | |||
TUSC5 Antibody (B-4) Alexa Fluor® 790 | sc-377025 AF790 | 200 µg/ml | $357.00 |