TSPEAR Antibody (A-10): sc-373868
- TSPEAR Antibody (A-10) is a mouse monoclonal IgG2a κ TSPEAR antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 22-57 near the N-terminus of TSPEAR of human origin
- TSPEAR Antibody (A-10) is recommended for detection of TSPEAR of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TSPEAR Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TSPEAR Antibody (A-10) for WB and IHC(P) applications. These reagents are now offered in bundles with TSPEAR Antibody (A-10) (see ordering information below).
QUICK LINKS
SEE ALSO...
TSPEAR Antibody (A-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects TSPEAR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TSPEAR (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TSPEAR protein, also known as C21orf9, is a 669 amino acid secreted protein that exists in two isoforms due to alternative splicing. TSPEAR features one Thrombospondin N-terminal domain and seven epilepsy-associated repeat (EAR) domains, which are significant as these domains are implicated in epilepsy pathogenesis. EAR domains in TSPEAR suggest a potential role in binding to an unidentified epileptic ligand or in disrupting axon synaptogenesis, processes crucial for normal neuronal function and connectivity. Understanding TSPEAR interactions and functions is vital, especially in seizure disorders, as these insights may reveal therapeutic targets for epilepsy treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TSPEAR Antibody (A-10) References:
- Channelopathies: episodic disorders of the nervous system. | Ptacek, L. 2002. Novartis Found Symp. 241: 87-104; discussion 104-8, 226-32. PMID: 11771653
- A common protein interaction domain links two recently identified epilepsy genes. | Scheel, H., et al. 2002. Hum Mol Genet. 11: 1757-62. PMID: 12095917
- Molecular genetics of human epilepsies. | Bate, L. and Gardiner, M. 1999. Expert Rev Mol Med. 1999: 1-22. PMID: 14585118
- The consensus coding sequences of human breast and colorectal cancers. | Sjöblom, T., et al. 2006. Science. 314: 268-74. PMID: 16959974
- Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. | Beckmann, G., et al. 1998. J Mol Biol. 275: 725-30. PMID: 9480764
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSPEAR Antibody (A-10) | sc-373868 | 200 µg/ml | $322.00 | |||
TSPEAR Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-525924 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSPEAR Antibody (A-10): m-IgG2a BP-HRP Bundle | sc-546459 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSPEAR Antibody (A-10) AC | sc-373868 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TSPEAR Antibody (A-10) HRP | sc-373868 HRP | 200 µg/ml | $322.00 | |||
TSPEAR Antibody (A-10) FITC | sc-373868 FITC | 200 µg/ml | $336.00 | |||
TSPEAR Antibody (A-10) PE | sc-373868 PE | 200 µg/ml | $349.00 | |||
TSPEAR Antibody (A-10) Alexa Fluor® 488 | sc-373868 AF488 | 200 µg/ml | $364.00 | |||
TSPEAR Antibody (A-10) Alexa Fluor® 546 | sc-373868 AF546 | 200 µg/ml | $364.00 | |||
TSPEAR Antibody (A-10) Alexa Fluor® 594 | sc-373868 AF594 | 200 µg/ml | $364.00 | |||
TSPEAR Antibody (A-10) Alexa Fluor® 647 | sc-373868 AF647 | 200 µg/ml | $364.00 | |||
TSPEAR Antibody (A-10) Alexa Fluor® 680 | sc-373868 AF680 | 200 µg/ml | $364.00 | |||
TSPEAR Antibody (A-10) Alexa Fluor® 790 | sc-373868 AF790 | 200 µg/ml | $364.00 | |||
TSPEAR (A-10) Neutralizing Peptide | sc-373868 P | 100 µg/0.5 ml | $69.00 |