TSG-6 Antibody (A6.6.11): sc-65887

TSG-6 Antibody (A6.6.11) is a rat monoclonal IgG2a antibody engineered to detect TSG-6, also known as TNF-stimulated gene 6 or tumor necrosis factor-inducible gene 6 protein, across mouse, rat, and human species using western blotting (WB) and immunoprecipitation (IP) techniques. TSG-6 is an extracellular glycoprotein that plays a pivotal role in modulating inflammation and maintaining extracellular matrix stability, which is crucial for processes such as tissue repair and the development of inflammatory conditions like rheumatoid arthritis. Located outside the cell, TSG-6 interacts with hyaluronan and forms stable complexes with inter-α-inhibitor (IαI), thereby regulating the protease network to suppress inflammatory responses. Anti-TSG-6 antibody (A6.6.11) targets an epitope raised against a CTLL-2 cell line expressing a CD44 chimera of human origin, ensuring robust and specific binding for accurate detection. The expression of TSG-6 is rapidly upregulated in response to pro-inflammatory cytokines such as TNFα and IL-1, underscoring its significance in immune responses and tissue remodeling. TSG-6 (A6.6.11) antibody is indispensable for researchers investigating the intricate mechanisms of inflammation and extracellular matrix interactions, providing reliable results in various experimental applications. Anti-TSG-6 antibody (A6.6.11) helps scientists gain deeper insights into the regulation and function of TSG-6 in both normal physiological processes and disease states, making this antibody an essential tool for advancing biomedical research.

The preferred TSG-6 antibody is TSG-6 Antibody (A38.1.20): sc-65886.