TSG-6 Antibody (A38.1.20): sc-65886
- TSG-6 Antibody (A38.1.20) is a rat monoclonal IgG2a, cited in 18 publications, provided at 200 µg/ml
- raised against a CTLL-2 cell line expressing CD44:TSG chimera of human origin
- Anti-TSG-6 Antibody (A38.1.20) is recommended for detection of TSG-6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ICF
- Anti-TSG-6 Antibody (A38.1.20) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TSG-6 Antibody (A38.1.20). This work is in progress.
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TSG-6 Antibody (A38.1.20) is a rat monoclonal IgG2a antibody designed to detect TSG-6, also known as TNF-stimulated gene 6 or tumor necrosis factor-inducible gene 6 protein, across mouse, rat, and human species. TSG-6 is a crucial glycoprotein involved in the modulation of inflammation and extracellular matrix stability, playing a significant role in processes such as wound healing and the pathogenesis of rheumatoid arthritis. Anti-TSG-6 antibody (A38.1.20) targets an epitope raised against a CTLL-2 cell line expressing a CD44 chimera of human origin, ensuring robust binding and detection. TSG-6 functions by interacting with hyaluronan and forming stable complexes with components of the inter-α-inhibitor (IαI), thereby potentiating the inhibition of protease activity and regulating the protease network to suppress inflammatory responses. The TSG-6 gene is actively transcribed in normal fibroblasts and is upregulated by pro-inflammatory cytokines like TNFα and IL-1, highlighting its importance in immune responses and tissue remodeling. TSG-6 monoclonal antibody (A38.1.20) is versatile in its applications, suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, TSG-6 (A38.1.20) antibody provides flexibility for diverse experimental needs. The high homology of TSG-6 to the adhesion receptor CD44, especially in the hyaluronic acid-binding domain, underscores its relevance in studying cell adhesion and migration. Anti-TSG-6 antibody (A38.1.20) enables researchers to effectively investigate the intricate mechanisms of inflammation and extracellular matrix interactions, making this tool essential for advancing biomedical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TSG-6 Antibody (A38.1.20) References:
- A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. | Lee, TH., et al. 1992. J Cell Biol. 116: 545-57. PMID: 1730767
- TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. | Wisniewski, HG., et al. 1994. Biochemistry. 33: 7423-9. PMID: 7516184
- NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. | Klampfer, L., et al. 1994. Mol Cell Biol. 14: 6561-9. PMID: 7935377
- TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis. | Wisniewski, HG., et al. 1993. J Immunol. 151: 6593-601. PMID: 8245487
- Transcriptional regulation of TSG6, a tumor necrosis factor- and interleukin-1-inducible primary response gene coding for a secreted hyaluronan-binding protein. | Lee, TH., et al. 1993. J Biol Chem. 268: 6154-60. PMID: 8454591
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSG-6 Antibody (A38.1.20) | sc-65886 | 200 µg/ml | $322.00 | |||
TSG-6 Antibody (A38.1.20) AC | sc-65886 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TSG-6 Antibody (A38.1.20) HRP | sc-65886 HRP | 200 µg/ml | $322.00 | |||
TSG-6 Antibody (A38.1.20) FITC | sc-65886 FITC | 200 µg/ml | $336.00 | |||
TSG-6 Antibody (A38.1.20) PE | sc-65886 PE | 200 µg/ml | $349.00 | |||
TSG-6 Antibody (A38.1.20) Alexa Fluor® 488 | sc-65886 AF488 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (A38.1.20) Alexa Fluor® 546 | sc-65886 AF546 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (A38.1.20) Alexa Fluor® 594 | sc-65886 AF594 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (A38.1.20) Alexa Fluor® 647 | sc-65886 AF647 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (A38.1.20) Alexa Fluor® 680 | sc-65886 AF680 | 200 µg/ml | $364.00 | |||
TSG-6 Antibody (A38.1.20) Alexa Fluor® 790 | sc-65886 AF790 | 200 µg/ml | $364.00 |