TSC-22 D4 Antibody (JJ-2): sc-101193

TSC-22 D4 Antibody (JJ-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects TSC-22 D4 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TSC-22 D4 antibody (JJ-2) is available as a non-conjugated format. TSC-22 D4, also known as transforming growth factor-beta-stimulated clone-22, plays a crucial role as a transcriptional regulator that modulates cell growth, differentiation, and apoptosis. TSC-22 D4 contains a leucine zipper domain and a nuclear export signal, which facilitate localization in the cytoplasm under normal conditions. During apoptosis, TSC-22 D4 translocates to the nucleus, where TSC-22 D4 exerts transcriptional regulatory functions. This dynamic localization underscores TSC-22 D4′s involvement in critical cellular processes, particularly in tumor suppression, given TSC-22 D4′s role as a downstream component in both the TGF-beta and PPARγ signaling pathways. Downregulation of TSC-22 mRNA in various cancer types highlights TSC-22 D4′s potential as an antiproliferative agent. TSC-22 D4, a 395 amino acid protein also referred to as TILZ2 and THG-1, functions primarily as a transcriptional repressor, making TSC-22 D4 an important target for research in cancer biology and therapeutic development.

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TSC-22 D4 Antibody (JJ-2) References:

1. Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator.  |  Hino, S., et al. 2000. Biochem Biophys Res Commun. 278: 659-64. PMID: 11095965
2. Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells.  |  Hino, S., et al. 2002. Oncol Rep. 9: 371-4. PMID: 11836610
3. Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22.  |  Gupta, RA., et al. 2003. J Biol Chem. 278: 7431-8. PMID: 12468551
4. Downregulation of putative tumor suppressor gene TSC-22 in human brain tumors.  |  Shostak, KO., et al. 2003. J Surg Oncol. 82: 57-64. PMID: 12501169
5. Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1.  |  Uchida, D., et al. 2003. Biochem Biophys Res Commun. 305: 846-54. PMID: 12767908
6. TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer.  |  Kawamata, H., et al. 2004. Curr Cancer Drug Targets. 4: 521-9. PMID: 15379637
7. Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.  |  Daouti, S., et al. 2005. Osteoarthritis Cartilage. 13: 508-18. PMID: 15922185
8. The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.  |  Yoon, HG. and Wong, J. 2006. Mol Endocrinol. 20: 1048-60. PMID: 16373395
9. Patterns of expression of TSC-22 protein in astrocytic gliomas.  |  Shostak, KO., et al. 2005. Exp Oncol. 27: 314-8. PMID: 16404353

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TSC-22 D4 Antibody (JJ-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TSC-22 D4 Antibody (JJ-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TSC-22 D4 Antibody (JJ-2) Specifications

Alternate Product Name: TSC22D4

Product Clone Name: JJ-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-396

Epitope Target: TSC-22 D4

Epitope Species: human

Product Reactivity/Detection: TSC-22 D4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TSC-22 D4 Antibody (JJ-2): N/A

The preferred GILZ antibody is GILZ Antibody (G-5): sc-133215.