TRP1 Antibody (F-9): sc-514911

TRP1 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects TRP1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, specifically in the formation of eumelanin, which is essential for pigmentation in hair, skin, and eyes. TRP1 is primarily located in the melanosomes of melanocytes, where TRP1 works in concert with other enzymes, including tyrosinase and TRP2, to facilitate the conversion of tyrosine to melanin. Proper localization of TRP1 within the melanosomal membrane is vital, as such positioning ensures efficient interaction with partner proteins and optimal enzymatic activity. Disruptions in TRP1 function or expression can lead to pigmentation disorders, highlighting TRP1′s importance in maintaining normal pigmentation and protecting against UV radiation. Anti-TRP1 antibody (F-9) is an invaluable tool for researchers studying melanin synthesis, pigmentation disorders, and the molecular mechanisms underlying these processes.

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TRP1 Antibody (F-9) References:

1. Investigation of the intracellular transport of tyrosinase and tyrosinase related protein (TRP)-1. The effect of endoplasmic reticulum (ER)-glucosidases inhibition.  |  Negroiu, G., et al. 1999. Cell Mol Biol (Noisy-le-grand). 45: 1001-10. PMID: 10644004
2. Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture.  |  Sarangarajan, R., et al. 2000. Pigment Cell Res. 13: 337-44. PMID: 11041210
3. SV-40 large T antigen reversibly inhibits expression of tyrosinase, TRP-1, TRP-2 and Mitf, but not Pax-3, in conditionally immortalized mouse melanocytes.  |  Prince, S., et al. 2001. Cell Biol Int. 25: 91-102. PMID: 11237412
4. Keratinocytes suppress TRP-1 expression and reduce cell number of co-cultured melanocytes - implications for grafting of patients with vitiligo.  |  Phillips, J., et al. 2001. Pigment Cell Res. 14: 116-25. PMID: 11310791
5. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity.  |  Dougan, SK., et al. 2013. Cancer Immunol Res. 1: 99-111. PMID: 24459675
6. Conformational and biological properties of the Ala10 analogue of human des-Trp1,Nle12-minigastrin.  |  Mammi, S., et al. 1989. Biochemistry. 28: 7182-8. PMID: 2819061
7. Coordinated mRNA expression of c-Kit with tyrosinase and TRP-1 in melanin pigmentation of normal and malignant human melanocytes and transient activation of tyrosinase by Kit/SCF-R.  |  Luo, D., et al. 1995. Melanoma Res. 5: 303-9. PMID: 8541720
8. Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line.  |  Zhao, H., et al. 1996. J Invest Dermatol. 106: 744-52. PMID: 8618015
9. Incomplete expression of the tyrosinase gene family (tyrosinase, TRP-1, and TRP-2) in human malignant melanoma cells in vitro.  |  Eberle, J., et al. 1995. Pigment Cell Res. 8: 307-13. PMID: 8789739
10. Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.  |  Orlow, SJ., et al. 1998. Cancer Res. 58: 1521-3. PMID: 9537258

The preferred TRP1 antibody is TRP1 Antibody (TA99): sc-58438.