TRP1 Antibody (3F388): sc-58437
- TRP1 Antibody (3F388) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against melenoma cell line SK-MEL-23 of human origin
- recommended for detection of TRP1 in melanomas of mouse, rat and human origin by WB and IF; non cross-reactive with carcinomas and sarcomas
- See TRP1 (G-9): sc-166857 for TRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRP1 Antibody (3F388) for WB applications. These reagents are now offered in bundles with TRP1 Antibody (3F388) (see ordering information below).
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TRP1 Antibody (3F388) is a mouse monoclonal IgG2a antibody that detects TRP1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, functioning as a melanogenic enzyme that contributes to the production of eumelanin and pheomelanin, the two primary types of melanin found in vertebrates. TRP1 is predominantly located in the melanosomes of melanocytes, where TRP1 works in concert with other enzymes, including tyrosinase and TRP2, to facilitate the complex process of melanin production. Proper localization of TRP1 within the melanosomal membrane is essential for enzymatic activity and stability, as such positioning ensures optimal interaction with substrates and other proteins involved in melanin synthesis. Deficiencies or mutations in TRP1 can lead to pigmentation disorders, highlighting TRP1′s importance in maintaining normal skin and hair color. Anti-TRP1 antibody (3F388) serves as an invaluable tool for researchers studying pigmentation, melanin biosynthesis, and related genetic conditions, providing reliable detection and characterization of TRP1 in various biological samples.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRP1 Antibody (3F388) | sc-58437 | 200 µg/ml | $316.00 | |||
TRP1 Antibody (3F388): m-IgG Fc BP-HRP Bundle | sc-537149 | 200 µg Ab; 10 µg BP | $354.00 | |||
TRP1 Antibody (3F388): m-IgGκ BP-HRP Bundle | sc-534344 | 200 µg Ab; 40 µg BP | $354.00 | |||
TRP1 Antibody (3F388): m-IgG2a BP-HRP Bundle | sc-547933 | 200 µg Ab; 10 µg BP | $354.00 |