Troponin T-FS Antibody (H-8): sc-166663
- Troponin T-FS Antibody (H-8) is a mouse monoclonal IgG2a κ Troponin T-FS antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 36-258 mapping at the C-terminus of fast skeletal muscle Troponin T of human origin
- Troponin T-FS Antibody (H-8) is recommended for detection of fast skeletal muscle Troponin T of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Troponin T-FS Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Troponin T-FS Antibody (H-8) for WB applications. These reagents are now offered in bundles with Troponin T-FS Antibody (H-8) (see ordering information below).
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Troponin T-FS Antibody (H-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Troponin T-FS of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Troponin T-FS antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Troponin T-FS plays a critical role in muscle contraction by facilitating the interaction between actin and myosin, which are essential for muscle fiber contraction and relaxation. The troponin complex, which includes Troponin C, Troponin I, and Troponin T, is vital for calcium-mediated regulation of muscle contraction. Troponin C acts as a calcium sensor, binding calcium ions and inducing conformational changes that allow myosin to interact with actin filaments. This interaction is crucial for various cellular movements, including muscle contraction, and is particularly important in cardiac and skeletal muscle function. Different isoforms of Troponin C, such as fast and slow, allow for fine-tuning of muscle responses to varying physiological demands, making Troponin T-FS monoclonal antibody (H-8) an invaluable tool for studying muscle physiology and pathophysiology in research and clinical settings.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Troponin T-FS Antibody (H-8) References:
- Structure and expression of the murine slow/cardiac troponin C gene. | Parmacek, MS. and Leiden, JM. 1989. J Biol Chem. 264: 13217-25. PMID: 2753913
- cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs. | Koppe, RI., et al. 1989. J Biol Chem. 264: 14327-33. PMID: 2760067
- A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction. | Potter, JD., et al. 1995. J Biol Chem. 270: 2557-62. PMID: 7852318
- Structure and regulation of the mouse cardiac troponin I gene. | Ausoni, S., et al. 1994. J Biol Chem. 269: 339-46. PMID: 8276817
- Actin cytoskeleton. Setting the pace of cell movement. | Barkalow, K. and Hartwig, JH. 1995. Curr Biol. 5: 1000-2. PMID: 8542272
- Myosins: matching functions with motors. | Baker, JP. and Titus, MA. 1998. Curr Opin Cell Biol. 10: 80-6. PMID: 9484598
- A new look at thin filament regulation in vertebrate skeletal muscle. | Squire, JM. and Morris, EP. 1998. FASEB J. 12: 761-71. PMID: 9657517
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Troponin T-FS Antibody (H-8) | sc-166663 | 200 µg/ml | $316.00 | |||
Troponin T-FS Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-529023 | 200 µg Ab; 10 µg BP | $354.00 | |||
Troponin T-FS Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-521699 | 200 µg Ab, 40 µg BP | $354.00 | |||
Troponin T-FS Antibody (H-8): m-IgG2a BP-HRP Bundle | sc-547238 | 200 µg Ab; 10 µg BP | $354.00 | |||
Troponin T-FS Antibody (H-8) AC | sc-166663 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Troponin T-FS Antibody (H-8) HRP | sc-166663 HRP | 200 µg/ml | $316.00 | |||
Troponin T-FS Antibody (H-8) FITC | sc-166663 FITC | 200 µg/ml | $330.00 | |||
Troponin T-FS Antibody (H-8) PE | sc-166663 PE | 200 µg/ml | $343.00 | |||
Troponin T-FS Antibody (H-8) Alexa Fluor® 488 | sc-166663 AF488 | 200 µg/ml | $357.00 | |||
Troponin T-FS Antibody (H-8) Alexa Fluor® 546 | sc-166663 AF546 | 200 µg/ml | $357.00 | |||
Troponin T-FS Antibody (H-8) Alexa Fluor® 594 | sc-166663 AF594 | 200 µg/ml | $357.00 | |||
Troponin T-FS Antibody (H-8) Alexa Fluor® 647 | sc-166663 AF647 | 200 µg/ml | $357.00 | |||
Troponin T-FS Antibody (H-8) Alexa Fluor® 680 | sc-166663 AF680 | 200 µg/ml | $357.00 | |||
Troponin T-FS Antibody (H-8) Alexa Fluor® 790 | sc-166663 AF790 | 200 µg/ml | $357.00 |