TRMT1 Antibody (F-8): sc-514876

TRMT1 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects TRMT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRMT1, also known as N(2),N(2)-dimethylguanosine tRNA methyltransferase, plays a crucial role in the modification of transfer RNA (tRNA), specifically by dimethylating a guanine residue at position 26, which is essential for maintaining the accuracy of mRNA translation. This modification helps regulate the efficiency of protein synthesis by ensuring that the ribosome reads the mRNA correctly, thereby preventing translational errors that could lead to dysfunctional proteins. TRMT1 consists of 659 amino acids and is primarily located in the nucleus, where TRMT1 is involved in the processing and modification of tRNA molecules. Notably, TRMT1 has two isoforms generated through alternative splicing, and TRMT1 gene is located on chromosome 19p13.13. Mutations in the TRMT1 gene can result in reduced enzyme activity and lower protein levels, which may have implications for cellular function and overall organismal health. anti-TRMT1 antibody (F-8) is an invaluable tool for researchers studying tRNA modifications and their impact on gene expression and protein synthesis.

The preferred TRMT1 antibody is TRMT1 Antibody (G-3): sc-373687.