TRIP6 Antibody (G-5): sc-376550

TRIP6 Antibody (G-5) is a mouse monoclonal IgG1 antibody that detects TRIP6 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TRIP6 is a crucial protein that plays a significant role in cellular signaling pathways, particularly in inflammation and immune responses. TRIP6 is predominantly localized in the cytoplasm and at focal adhesion sites, where TRIP6 interacts with various signaling molecules, including receptor-interacting protein 2 (RIP2) and tumor necrosis factor receptor-associated factor 2 (TRAF2). TRIP6 localization allows for the integration of signals from extracellular stimuli, facilitating the activation of downstream pathways such as NF-kappaB and ERK. This spatial regulation is essential for proper cellular responses to inflammatory signals, and dysregulation of TRIP6 has been implicated in various pathological conditions, including cancer and autoimmune diseases. Anti-TRIP6 antibody (G-5) enables researchers to effectively study TRIP6 dynamics in different cellular contexts, contributing to a deeper understanding of TRIP6′s role in health and disease.

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TRIP6 Antibody (G-5) References:

1. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.  |  Xu, J., et al. 2004. J Biol Chem. 279: 10459-68. PMID: 14688263
2. The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.  |  Lai, YJ., et al. 2010. Mol Cell Biol. 30: 5582-96. PMID: 20876301
3. TRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation.  |  Lin, FT., et al. 2016. Cell Discov. 2: 15048-. PMID: 27134758
4. TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.  |  Gou, H., et al. 2019. Cancer Res. 79: 3332-3346. PMID: 31018940
5. TRIP6, as a target of miR-7, regulates the proliferation and metastasis of colorectal cancer cells.  |  Ling, Y., et al. 2019. Biochem Biophys Res Commun. 514: 231-238. PMID: 31029422
6. TRIP6 regulates the proliferation, migration, invasion and apoptosis of osteosarcoma cells by activating the NF-κB signaling pathway.  |  Liu, W., et al. 2020. Exp Ther Med. 19: 2317-2325. PMID: 32104300
7. TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.  |  Lu, X., et al. 2023. J Hepatocell Carcinoma. 10: 1281-1293. PMID: 37554583
8. TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation.  |  Li, MY., et al. 2024. FASEB J. 38: e23501. PMID: 38411462
9. High Expression Level of TRIP6 is Correlated with Poor Prognosis in Colorectal Cancer and Promotes Tumor Cell Proliferation and Migration.  |  Ren, H., et al. 2025. Biochem Genet. 63: 261-280. PMID: 38430448
10. The TRIP6/LATS1 complex constitutes the tension sensor of α-catenin/vinculin at both bicellular and tricellular junctions.  |  Xie, L., et al. 2024. Eur J Cell Biol. 103: 151426. PMID: 38805800

The preferred TRIP6 antibody is TRIP6 Antibody (F-5): sc-365122.