TRIP6 Antibody (F-10): sc-365972

TRIP6 Antibody (F-10) is a mouse monoclonal IgG1 antibody that detects TRIP6 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TRIP6 is a crucial protein that plays a significant role in cellular signaling pathways, particularly in inflammation and immune responses. TRIP6 is primarily localized in the cytoplasm and at focal adhesion sites, where TRIP6 interacts with various signaling molecules, influencing cell adhesion and migration. TRIP6′s presence at focal adhesions allows modulation of assembly and disassembly of these structures, which are essential for maintaining tissue integrity and facilitating cellular communication. Additionally, TRIP6′s interactions with proteins such as receptor-interacting protein 2 (RIP2) and TRAF2 highlight TRIP6′s role in mediating downstream signaling events, including the activation of NFkappaB, a key transcription factor involved in inflammatory responses. Understanding TRIP6′s localization and function helps researchers gain insights into TRIP6′s contributions to various physiological and pathological processes, making anti-TRIP6 antibody (F-10) an invaluable tool for studying these mechanisms in human tissues.

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TRIP6 Antibody (F-10) References:

1. The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.  |  Cuppen, E., et al. 2000. Eur J Cell Biol. 79: 283-93. PMID: 10826496
2. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters.  |  Kassel, O., et al. 2004. Genes Dev. 18: 2518-28. PMID: 15489293
3. Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.  |  Takizawa, N., et al. 2006. J Cell Biol. 174: 447-58. PMID: 16880273
4. c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation.  |  McMichael, BK., et al. 2010. J Biol Chem. 285: 26641-51. PMID: 20547766
5. LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection.  |  Sheppard, SA. and Loayza, D. 2010. Aging (Albany NY). 2: 432-44. PMID: 20634563
6. TRIP6 and LPP, but not Zyxin, are present at a subset of telomeres in human cells.  |  Sheppard, SA., et al. 2011. Cell Cycle. 10: 1726-30. PMID: 21519191
7. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.  |  Lin, Y., et al. 2021. Biochem Biophys Res Commun. 550: 62-69. PMID: 33684622
8. Circ_0079471 Regulates the Proliferation, Migration, Invasion and Apoptosis of Osteosarcoma Cells by Mediating miR-485-3p and TRIP6.  |  Liu, W., et al. 2025. Curr Med Chem. 32: 1208-1222. PMID: 38178663
9. The ability of the LIMD1 and TRIP6 LIM domains to bind strained f-actin is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1.  |  Ray, S., et al. 2024. Cytoskeleton (Hoboken). 81: 436-447. PMID: 38426816
10. The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis.  |  Yi, J. and Beckerle, MC. 1998. Genomics. 49: 314-6. PMID: 9598321

The preferred TRIP6 antibody is TRIP6 Antibody (F-5): sc-365122.